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Peptide record

TPDB02417

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB02417
Antibacterial Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept dbAMP 3.0 APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FFGSLLSLGSKLLPSVFKLFQRKKE
Physicochemical Analysis
C138H221N33O33
ANDCHIMTWY
L
2870.47
10.98
5
1
11
+4
0.55
0.220
105.20
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
5
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
1
E
1
Q
2
G
0
H
0
I
6
L
4
K
0
M
4
F
1
P
4
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 2 H: 0 I: 0 L: 6 K: 4 M: 0 F: 4 P: 1 S: 4 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
25
C138H221N33O33
2870.47
10.98
+4
0.55
0.220
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
12.5 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli and S. aureus (MIC 12.5 ug/ml). Also active against C. albicans KCTC 7270 or fuconazole-resistant strains CCARM 14001 or
Evidence 2 Activity

Activity

MIC
Antifungal
12.5 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli and S. aureus (MIC 12.5 ug/ml). Also active against C. albicans KCTC 7270 or fuconazole-resistant strains CCARM 14001 or
Evidence 3 Activity

Activity

MIC
Antiparasitic
12.5 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against E. coli and S. aureus (MIC 12.5 ug/ml). Also active against C. albicans KCTC 7270 or fuconazole-resistant strains CCARM 14001 or
Evidence 4 Activity

Activity

% Hemolysis
Hemolysis
30 67 %
[Ref.23093034]30% hemolytic activity at 9 µM, 67% hemolytic activity at 17 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
J Antibiot (Tokyo). 2013 Jan 66(1):3-10.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 5 Activity

Activity

40% Hemolysis
Toxicity
16 µM
Hemolytic Cytotoxic
40% Hemolysis | 16 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Scorpion-Venom-Derived Antimicrobial Peptide Css54 Exerts Potent Antimicrobial Activity by Disrupting Bacterial Membrane of Zoonotic Bacteria. | Antibiotics (Basel) | 2020
Evidence 6 Activity

Activity

50% Cell death
Toxicity
8 µM
Cytotoxic
50% Cell death | 8 | µM | target cell: Pig kidney epithelial cells PK15

Target

Pig kidney epithelial cells PK15

Source & Reference

NA
DBAASP
Scorpion-Venom-Derived Antimicrobial Peptide Css54 Exerts Potent Antimicrobial Activity by Disrupting Bacterial Membrane of Zoonotic Bacteria. | Antibiotics (Basel) | 2020
Evidence 7 Activity

Activity

83% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
83% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptides from arachnid venoms and their microbicidal activity in the presence of commercial antibiotics. | J Antibiot (Tokyo) | 2013
Evidence 8 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.23093034]30% hemolytic activity at 9 µM, 67% hemolytic activity at 17 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
J Antibiot (Tokyo). 2013 Jan 66(1):3-10.
Evidence 9 Hemolysis

Activity

30 67 %
% Hemolysis
[Ref.23093034]30% hemolytic activity at 9 µM, 67% hemolytic activity at 17 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
J Antibiot (Tokyo). 2013 Jan 66(1):3-10.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.