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Peptide record

TPDB02415

Antibacterial Anticancer Antidiabetic Antifungal Antiparasitic Hemolysis Toxicity standard
46 amino acids
Basic Information
3D PDB MODEL
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TPDB02415
Antibacterial Anticancer Antidiabetic Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP pep-lab Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 46-aa standard natural multi-activity (Antibacterial, Anticancer, Antidiabetic, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GIFSKLGRKKIKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC
Physicochemical Analysis
C215H378N62O60S3
QHPWY
GK
4887.93
10.32
10
4
17
+6
11.53
0.083
112.17
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
2.56
7
Residue Composition
number
1
A
2
R
2
N
2
D
2
C
2
E
0
Q
8
G
0
H
6
I
4
L
8
K
1
M
1
F
0
P
2
S
1
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 1 R: 2 N: 2 D: 2 C: 2 E: 2 Q: 0 G: 8 H: 0 I: 6 L: 4 K: 8 M: 1 F: 1 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 4
Chemical Descriptors
46
C215H378N62O60S3
4887.93
10.32
+6
11.53
0.083
Evidence Records 7 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Zone inhibition assays: Active against E. coli D 21(lethal concentration LC 0.2 uM), B. megaterium BmII (LC 0.1 uM), S. aureus Cowan 1(LC 0.4 uM), P. aeruginosa ATCC15692 (LC 0.7 uM), C. albicans (LC 0.5 uM) and S. cerevisiae (LC 0.9 uM). (LC=lethal concentration, data provided by Chunfeng Wang).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Zone inhibition assays: Active against E. coli D 21(lethal concentration LC 0.2 uM), B. megaterium BmII (LC 0.1 uM), S. aureus Cowan 1(LC 0.4 uM), P. aeruginosa ATCC15692 (LC 0.7 uM), C. albicans (LC 0.5 uM) and S. cerevisiae (LC 0.9 uM). (LC=lethal concentration, data provided by Chunfeng Wang).
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

Zone inhibition assays: Active against E. coli D 21(lethal concentration LC 0.2 uM), B. megaterium BmII (LC 0.1 uM), S. aureus Cowan 1(LC 0.4 uM), P. aeruginosa ATCC15692 (LC 0.7 uM), C. albicans (LC 0.5 uM) and S. cerevisiae (LC 0.9 uM). (LC=lethal concentration, data provided by Chunfeng Wang).
Evidence 4 Activity

Activity

Hemolysis
[Ref. 8163497] LC>100µM

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
FEBS Lett. 1993 Jun 14 324(2):159-161.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 5 Activity

Activity

100% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
100% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel antimicrobial peptides from skin secretion of the European frog Rana esculenta. | FEBS Lett | 1993
Evidence 6 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref. 8163497] LC>100µM

Target

erythrocytes

Source & Reference

NA
DRAMP
FEBS Lett. 1993 Jun 14 324(2):159-161.
Evidence 7 Hemolysis

Activity

[Ref. 8163497] LC>100µM
Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
FEBS Lett. 1993 Jun 14 324(2):159-161.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.