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Peptide record

TPDB02406

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard

41 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB02406

Activity

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP pep-lab Peptipedia Antifungipept i2APP APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 41-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GILDTIKSIASKVWNSKTVQDLKRKGINWVANKLGVSPQAA

FASTA

>TPDB02406|Antibacterial;Anticancer;Antifungal;Antiparasitic;Hemolysis;Toxicity|length=41
GILDTIKSIASKVWNSKTVQDLKRKGINWVANKLGVSPQAA

Formula C199H333N57O57

Absent Amino Acids CEHMFY

Common Amino Acids K

Mass 4436.18

PI 10.82

Basic Residues 7

Acidic Residues 2

Hydrophobic Residues 17

Net Charge +5

Boman Index 5.89

Hydrophobicity -0.200

Aliphatic Index 104.63

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 11000

Absorbance 280nm 247.96

Polar Residues 11

number

Amino Acid Distribution

A: 4 R: 1 N: 3 D: 2 C: 0 E: 0 Q: 2 G: 3 H: 0 I: 4 L: 3 K: 6 M: 0 F: 0 P: 1 S: 4 T: 2 W: 2 Y: 0 V: 4

Length

Formula

C199H333N57O57

Mass

4436.18

10.82

Net Charge

Boman Index

5.89

Hydrophobicity

-0.200

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 10 µM

Target

Target Organism Escherichia coli ATCC 25926

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli ATCC 25926 (MIC 10 uM), S. marscencens ATCC 13880 (MIC 10 uM), E. cloacae 129 (MIC 10 uM), S. thyphi (MIC 40 uM)

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 10 µM

Target

Target Organism S. marscencens ATCC 13880

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli ATCC 25926 (MIC 10 uM), S. marscencens ATCC 13880 (MIC 10 uM), E. cloacae 129 (MIC 10 uM), S. thyphi (MIC 40 uM), and K. pneumoniae (MIC 40 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 10 µM

Target

Target Organism Enterobacter cloacae 129

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli ATCC 25926 (MIC 10 uM), S. marscencens ATCC 13880 (MIC 10 uM), E. cloacae 129 (MIC 10 uM), S. thyphi (MIC 40 uM), and K. pneumoniae (MIC 40 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 40 µM

Target

Target Organism S. thyphi

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

TCC 25926 (MIC 10 uM), S. marscencens ATCC 13880 (MIC 10 uM), E. cloacae 129 (MIC 10 uM), S. thyphi (MIC 40 uM), and K. pneumoniae (MIC 40 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 40 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

arscencens ATCC 13880 (MIC 10 uM), E. cloacae 129 (MIC 10 uM), S. thyphi (MIC 40 uM), and K. pneumoniae (MIC 40 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 10 µM

Target

Target Organism Escherichia coli ATCC 25926

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli ATCC 25926 (MIC 10 uM), S. marscencens ATCC 13880 (MIC 10 uM), E. cloacae 129 (MIC 10 uM), S. thyphi (MIC 40 uM)

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 10 µM

Target

Target Organism S. marscencens ATCC 13880

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Active against E. coli ATCC 25926 (MIC 10 uM), S. marscencens ATCC 13880 (MIC 10 uM), E. cloacae 129 (MIC 10 uM), S. thyphi (MIC 40 uM), and K. pneumoniae (MIC 40 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 10 µM

Target

Target Organism Enterobacter cloacae 129

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Active against E. coli ATCC 25926 (MIC 10 uM), S. marscencens ATCC 13880 (MIC 10 uM), E. cloacae 129 (MIC 10 uM), S. thyphi (MIC 40 uM), and K. pneumoniae (MIC 40 uM).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 40 µM

Target

Target Organism S. thyphi

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

TCC 25926 (MIC 10 uM), S. marscencens ATCC 13880 (MIC 10 uM), E. cloacae 129 (MIC 10 uM), S. thyphi (MIC 40 uM), and K. pneumoniae (MIC 40 uM).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 40 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

arscencens ATCC 13880 (MIC 10 uM), E. cloacae 129 (MIC 10 uM), S. thyphi (MIC 40 uM), and K. pneumoniae (MIC 40 uM).

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 10 µM

Target

Target Organism Escherichia coli ATCC 25926

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against E. coli ATCC 25926 (MIC 10 uM), S. marscencens ATCC 13880 (MIC 10 uM), E. cloacae 129 (MIC 10 uM), S. thyphi (MIC 40 uM)

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 10 µM

Target

Target Organism S. marscencens ATCC 13880

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli ATCC 25926 (MIC 10 uM), S. marscencens ATCC 13880 (MIC 10 uM), E. cloacae 129 (MIC 10 uM), S. thyphi (MIC 40 uM), and K. pneumoniae (MIC 40 uM).

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 10 µM

Target

Target Organism Enterobacter cloacae 129

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli ATCC 25926 (MIC 10 uM), S. marscencens ATCC 13880 (MIC 10 uM), E. cloacae 129 (MIC 10 uM), S. thyphi (MIC 40 uM), and K. pneumoniae (MIC 40 uM).

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 40 µM

Target

Target Organism S. thyphi

Source & Reference

Database Source DRAMP

Other

Evidence Text

TCC 25926 (MIC 10 uM), S. marscencens ATCC 13880 (MIC 10 uM), E. cloacae 129 (MIC 10 uM), S. thyphi (MIC 40 uM), and K. pneumoniae (MIC 40 uM).

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 40 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source DRAMP

Other

Evidence Text

arscencens ATCC 13880 (MIC 10 uM), E. cloacae 129 (MIC 10 uM), S. thyphi (MIC 40 uM), and K. pneumoniae (MIC 40 uM).

Evidence 16 Activity

Activity

Activity Endpoint 80% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 20 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

80% Hemolysis | 20 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Hadrurin, a new antimicrobial peptide from the venom of the scorpion Hadrurus aztecus. | Eur J Biochem | 2000

Evidence 17 Hemolysis

Source & Reference

source APD_complete APD_hemolytic HemoPI PD_Hemolysis

Database Source APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.