Back to search

Peptide record

TPDB02403

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB02403
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifp Antifungipept APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLPLLLAGLPKLLCLFFKKC
Physicochemical Analysis
C114H185N23O21S2
RNDEQHIMSTWYV
L
2277.98
9.80
3
0
12
+3
-4.64
1.515
161.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
5.49
2
Residue Composition
number
1
A
0
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
0
I
8
L
3
K
0
M
3
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 8 K: 3 M: 0 F: 3 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
20
C114H185N23O21S2
2277.98
9.80
+3
-4.64
1.515
Evidence Records 7 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E. coli and S. aureus (MIC < 15 uM) and hemolytic. Updated 5/2020
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against E. coli and S. aureus (MIC < 15 uM) and hemolytic. Updated 5/2020
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

Active against E. coli and S. aureus (MIC < 15 uM) and hemolytic. Updated 5/2020
Evidence 4 Activity

Activity

LC50
Hemolysis
7 µM
[Ref.17688900]LC50<7 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Toxicon. 2007 Nov 50(6):746-756.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
<5 µM
Hemolytic Cytotoxic
50% Hemolysis | <5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cytolytic peptides belonging to the brevinin-1 and brevinin-2 families isolated from the skin of the Japanese brown frog, Rana dybowskii. | Toxicon | 2007
Evidence 6 Activity

Activity

LC50
Toxicity
7 µM
Hemolytic
Hemolytic_activity: [Ref.17688900]LC50<7 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Toxicon. 2007 Nov 50(6):746-756.
Evidence 7 Hemolysis

Activity

7 µM
LC50
[Ref.17688900]LC50<7 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Toxicon. 2007 Nov 50(6):746-756.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.