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Peptide record

TPDB02399

Antibacterial Anticancer Antifungal Antiparasitic standard

23 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB02399

Activity

Antibacterial Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GLWQKIKSAAGDLASGIVEAIKS

FASTA

>TPDB02399|Antibacterial;Anticancer;Antifungal;Antiparasitic|length=23
GLWQKIKSAAGDLASGIVEAIKS

Formula C105H176N28O32

Absent Amino Acids RNCHMFPTY

Common Amino Acids A

Mass 2342.72

PI 9.76

Basic Residues 3

Acidic Residues 2

Hydrophobic Residues 11

Net Charge +1

Boman Index 2.71

Hydrophobicity 0.252

Aliphatic Index 114.78

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 234.77

Polar Residues 4

number

Amino Acid Distribution

A: 4 R: 0 N: 0 D: 1 C: 0 E: 1 Q: 1 G: 3 H: 0 I: 3 L: 2 K: 3 M: 0 F: 0 P: 0 S: 3 T: 0 W: 1 Y: 0 V: 1

Length

Formula

C105H176N28O32

Mass

2342.72

9.76

Net Charge

Boman Index

2.71

Hydrophobicity

0.252

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism B.cereus

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), E. coli (MIC 50 ug/ml), L.lactis (MIC >100 uM), L.innocua (MIC >100 ug/ml), M. luteus (M

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), E. coli (MIC 50 ug/ml), L.lactis (MIC >100 uM), L.innocua (MIC >100 ug/ml), M. luteus (MIC 6 ug/ml, S.aureus ATC

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µM

Target

Target Organism L.lactis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), E. coli (MIC 50 ug/ml), L.lactis (MIC >100 uM), L.innocua (MIC >100 ug/ml), M. luteus (MIC 6 ug/ml, S.aureus ATCC 25923 (MIC >100 ug/ml)

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism L.innocua

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

tivity against B.cereus (MIC >100 ug/ml), E. coli (MIC 50 ug/ml), L.lactis (MIC >100 uM), L.innocua (MIC >100 ug/ml), M. luteus (MIC 6 ug/ml, S.aureus ATCC 25923 (MIC >100 ug/ml), S.epidermidis (MIC >100 ug

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism S.aureus ATCC 25923

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

IC 50 ug/ml), L.lactis (MIC >100 uM), L.innocua (MIC >100 ug/ml), M. luteus (MIC 6 ug/ml, S.aureus ATCC 25923 (MIC >100 ug/ml), S.epidermidis (MIC >100 ug/ml), S.uberis (MIC >100 ug/ml), E.clocae (MIC >100 ug/ml), P.

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism S.epidermidis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

L.innocua (MIC >100 ug/ml), M. luteus (MIC 6 ug/ml, S.aureus ATCC 25923 (MIC >100 ug/ml), S.epidermidis (MIC >100 ug/ml), S.uberis (MIC >100 ug/ml), E.clocae (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), and P

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism S.uberis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

uteus (MIC 6 ug/ml, S.aureus ATCC 25923 (MIC >100 ug/ml), S.epidermidis (MIC >100 ug/ml), S.uberis (MIC >100 ug/ml), E.clocae (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), and P. haemolytica (MIC <0.4 ug/

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism E.clocae

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

s ATCC 25923 (MIC >100 ug/ml), S.epidermidis (MIC >100 ug/ml), S.uberis (MIC >100 ug/ml), E.clocae (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), and P. haemolytica (MIC <0.4 ug/ml).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism P.multocida

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

l), S.epidermidis (MIC >100 ug/ml), S.uberis (MIC >100 ug/ml), E.clocae (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), and P. haemolytica (MIC <0.4 ug/ml).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement <0.4 µg/mL

Target

Target Organism P. haemolytica

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

), S.uberis (MIC >100 ug/ml), E.clocae (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), and P. haemolytica (MIC <0.4 ug/ml).

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism B.cereus

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), E. coli (MIC 50 ug/ml), L.lactis (MIC >100 uM), L.innocua (MIC >100 ug/ml), M. luteus (M

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 50 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), E. coli (MIC 50 ug/ml), L.lactis (MIC >100 uM), L.innocua (MIC >100 ug/ml), M. luteus (MIC 6 ug/ml, S.aureus ATC

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µM

Target

Target Organism L.lactis

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), E. coli (MIC 50 ug/ml), L.lactis (MIC >100 uM), L.innocua (MIC >100 ug/ml), M. luteus (MIC 6 ug/ml, S.aureus ATCC 25923 (MIC >100 ug/ml)

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism L.innocua

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism S.aureus ATCC 25923

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism S.epidermidis

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism S.uberis

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism E.clocae

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

s ATCC 25923 (MIC >100 ug/ml), S.epidermidis (MIC >100 ug/ml), S.uberis (MIC >100 ug/ml), E.clocae (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), and P. haemolytica (MIC <0.4 ug/ml).

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism P.multocida

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

l), S.epidermidis (MIC >100 ug/ml), S.uberis (MIC >100 ug/ml), E.clocae (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), and P. haemolytica (MIC <0.4 ug/ml).

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement <0.4 µg/mL

Target

Target Organism P. haemolytica

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

), S.uberis (MIC >100 ug/ml), E.clocae (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), and P. haemolytica (MIC <0.4 ug/ml).

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism B.cereus

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), E. coli (MIC 50 ug/ml), L.lactis (MIC >100 uM), L.innocua (MIC >100 ug/ml), M. luteus (M

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 50 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), E. coli (MIC 50 ug/ml), L.lactis (MIC >100 uM), L.innocua (MIC >100 ug/ml), M. luteus (MIC 6 ug/ml, S.aureus ATC

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µM

Target

Target Organism L.lactis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), E. coli (MIC 50 ug/ml), L.lactis (MIC >100 uM), L.innocua (MIC >100 ug/ml), M. luteus (MIC 6 ug/ml, S.aureus ATCC 25923 (MIC >100 ug/ml)

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism L.innocua

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism S.aureus ATCC 25923

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism S.epidermidis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism S.uberis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism E.clocae

Source & Reference

Database Source DRAMP

Other

Evidence Text

s ATCC 25923 (MIC >100 ug/ml), S.epidermidis (MIC >100 ug/ml), S.uberis (MIC >100 ug/ml), E.clocae (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), and P. haemolytica (MIC <0.4 ug/ml).

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism P.multocida

Source & Reference

Database Source DRAMP

Other

Evidence Text

l), S.epidermidis (MIC >100 ug/ml), S.uberis (MIC >100 ug/ml), E.clocae (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), and P. haemolytica (MIC <0.4 ug/ml).

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement <0.4 µg/mL

Target

Target Organism P. haemolytica

Source & Reference

Database Source DRAMP

Other

Evidence Text

), S.uberis (MIC >100 ug/ml), E.clocae (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), and P. haemolytica (MIC <0.4 ug/ml).