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Peptide record

TPDB02391

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB02391
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb i2APP APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GFMKYIGPLIPHAVKAISDLI
Physicochemical Analysis
C109H175N25O26S1
RNCEQTW
I
2283.80
9.65
3
1
12
+1
0.29
0.833
134.76
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
65.24
2
Residue Composition
number
2
A
0
R
0
N
1
D
0
C
0
E
0
Q
2
G
1
H
4
I
2
L
2
K
1
M
1
F
2
P
1
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 4 L: 2 K: 2 M: 1 F: 1 P: 2 S: 1 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
21
C109H175N25O26S1
2283.80
9.65
+1
0.29
0.833
Evidence Records 6 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
65 µM
Hemolytic Cytotoxic
50% Hemolysis | 65 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial and cytolytic properties of the frog skin peptide, kassinatuerin-1 and its L- and D-lysine-substituted derivatives. | Peptides | 2005
Evidence 2 Activity

Activity

50% Cell death
Toxicity
12 µM
Cytotoxic
50% Cell death | 12 | µM | target cell: Mouse fibroblasts L929

Target

Mouse fibroblasts L929

Source & Reference

NA
DBAASP
Antimicrobial and cytolytic properties of the frog skin peptide, kassinatuerin-1 and its L- and D-lysine-substituted derivatives. | Peptides | 2005
Evidence 3 Activity

Activity

39% Hemolysis
Toxicity
400 µM
Hemolytic Cytotoxic
39% Hemolysis | 400 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial and cytolytic properties of the frog skin peptide, kassinatuerin-1 and its L- and D-lysine-substituted derivatives. | Peptides | 2005
Evidence 4 Activity

Activity

50% Cell death
Toxicity
105 µM
Cytotoxic
50% Cell death | 105 | µM | target cell: Mouse fibroblasts L929

Target

Mouse fibroblasts L929

Source & Reference

NA
DBAASP
Antimicrobial and cytolytic properties of the frog skin peptide, kassinatuerin-1 and its L- and D-lysine-substituted derivatives. | Peptides | 2005
Evidence 5 Activity

Activity

LD50
Toxicity
12 µM
Cytotoxic
Cytotoxicity: [Ref.15885852]Display cytotoxicity against L929 fibroblasts (LD50=12µM).

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 2000 Feb 16 268(2):433-436.##Peptides. 2005 Nov 26(11):2104-2110.
Evidence 6 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.