TPDB

3D PDB MODEL

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TPDB ID TPDB02390

Peptide_Name

Raniseptin-6

Activity

Antibacterial Anticancer

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP Peptipedia CancerPPD 2.0 dbACP

Sequence_Type

standard

Has_Modification No

Description A 29-aa standard natural multi-activity (Antibacterial and Anticancer) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.

Sequence

ALLDKLKSLGKVVGKVALGVVQNYLNPRQ

FASTA

>TPDB02390|Antibacterial;Anticancer|length=29
ALLDKLKSLGKVVGKVALGVVQNYLNPRQ

Formula C142H246N40O38

Absent Amino Acids CEHIMFTW

Common Amino Acids L

Mass 3121.76

PI 10.63

Basic Residues 5

Acidic Residues 1

Hydrophobic Residues 14

Net Charge +4

Boman Index 4.32

Hydrophobicity 0.169

Aliphatic Index 137.59

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 47.73

Polar Residues 6

number

2

A

1

R

2

N

1

D

0

C

0

E

2

Q

3

G

0

H

0

I

6

L

4

K

0

M

0

F

1

P

1

S

0

T

0

W

1

Y

5

V

Amino Acid Distribution

A: 2 R: 1 N: 2 D: 1 C: 0 E: 0 Q: 2 G: 3 H: 0 I: 0 L: 6 K: 4 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 1 V: 5

Length

29

Formula

C142H246N40O38

Mass

3121.76

PI

10.63

Net Charge

+4

Boman Index

4.32

Hydrophobicity

0.169

C_terminal_Modification

Free

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial and Antitumor

Origin

Boana raniceps

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Gram- E. coli ATCC 25922 (MIC 2 uM), K. pneumoniae ATCC 13883 (MIC 1 uM), K. pneumoniae ATCC 13883 (MIC 4 uM), Gram+ S. aureu

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1 µM

Target

Target Organism Klebsiella pneumoniae ATCC 13883

Source & Reference

Database Source dbAMP

Other

Evidence Text

Gram- E. coli ATCC 25922 (MIC 2 uM), K. pneumoniae ATCC 13883 (MIC 1 uM), K. pneumoniae ATCC 13883 (MIC 4 uM), Gram+ S. aureus ATCC 25923 (MIC 32 uM), S. epidermi

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism Klebsiella pneumoniae ATCC 13883

Source & Reference

Database Source dbAMP

Other

Evidence Text

Gram- E. coli ATCC 25922 (MIC 2 uM), K. pneumoniae ATCC 13883 (MIC 1 uM), K. pneumoniae ATCC 13883 (MIC 4 uM), Gram+ S. aureus ATCC 25923 (MIC 32 uM), S. epidermidis ATCC 12228 (MIC 8 uM), and yeast

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 32 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source dbAMP

Other

Evidence Text

IC 2 uM), K. pneumoniae ATCC 13883 (MIC 1 uM), K. pneumoniae ATCC 13883 (MIC 4 uM), Gram+ S. aureus ATCC 25923 (MIC 32 uM), S. epidermidis ATCC 12228 (MIC 8 uM), and yeast C.albicans ATCC 14053 (MIC > 128 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism Staphylococcus epidermidis ATCC 12228

Source & Reference

Database Source dbAMP

Other

Evidence Text

(MIC 1 uM), K. pneumoniae ATCC 13883 (MIC 4 uM), Gram+ S. aureus ATCC 25923 (MIC 32 uM), S. epidermidis ATCC 12228 (MIC 8 uM), and yeast C.albicans ATCC 14053 (MIC > 128 uM).

Evidence 6 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 8.69 uM

Detail Source Activity Anticancer

Activity Measurement 8.69 µM

Target

Cancer Type Skin Cancer

Cell Line B16-F10

Tissue Affected Skin

Assay & Model

Assay MTT assay

Testing Time 3-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2023

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.