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Peptide record

TPDB02380

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Hemolysis Toxicity standard

10 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB02380

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF CAFPdb i2APP AVPpred-BWR CellPPD-MOD APD_complete PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 10-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GLLKRIKTLL

FASTA

>TPDB02380|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Cell-penetrating Peptides;Hemolysis;Toxicity|length=10
GLLKRIKTLL

Formula C54H103N15O12

Absent Amino Acids ANDCEQHMFPSWYV

Common Amino Acids L

Mass 1154.51

PI 11.64

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +3

Boman Index 0.39

Hydrophobicity 0.630

Aliphatic Index 195.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 4 K: 2 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0

Length

Formula

C54H103N15O12

Mass

1154.51

11.64

Net Charge

Boman Index

0.39

Hydrophobicity

0.630

Evidence 1 Activity

Activity

Activity Endpoint 0% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Synthesis and biological activity of lipophilic analogs of the cationic antimicrobial active peptide anoplin. | J Pept Sci | 2016

Evidence 2 Activity

Activity

Activity Endpoint 8% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 200 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

8% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Synthesis and biological activity of lipophilic analogs of the cationic antimicrobial active peptide anoplin. | J Pept Sci | 2016

Evidence 3 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 300-500 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 300-500 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Synthesis and biological activity of lipophilic analogs of the cationic antimicrobial active peptide anoplin. | J Pept Sci | 2016

Evidence 4 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 210.63 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 210.63 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 5 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement >256 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | >256 | µM | target cell: Human glomerular mesangial cells (GMC)

Target

Target Cell Human glomerular mesangial cells (GMC)

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 6 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 11.38 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 11.38 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 7 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >256 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | >256 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 8 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 2407.73 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 2407.73 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Evidence 9 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >500 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | >500 | µg/mL | target cell: Sheep erythrocytes

Target

Target Cell Sheep erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Improving the biological activity of the antimicrobial peptide anoplin by membrane anchoring through a lipophilic amino acid derivative. | Bioorg Med Chem Lett | 2013

Evidence 10 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >64 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | >64 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Improved bioactivity of antimicrobial peptides by addition of amino-terminal copper and nickel (ATCUN) binding motifs. | ChemMedChem | 2014

Evidence 11 Activity

Activity

Activity Endpoint 30% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 32 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

30% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Copper-binding tripeptide motif increases potency of the antimicrobial peptide Anoplin via Reactive Oxygen Species generation. | Biochem Biophys Res Commun | 2015

Evidence 12 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >256 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | >256 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity. | Eur J Med Chem | 2019

Evidence 13 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 256 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 256 | µM | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antimicrobial peptides conjugated with fatty acids on the side chain of D-amino acid promises antimicrobial potency against multidrug-resistant bacteria. | Eur J Pharm Sci | 2020

Evidence 14 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement >256 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | >256 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Target Cell Human embryonic kidney HEK293T cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antimicrobial peptides conjugated with fatty acids on the side chain of D-amino acid promises antimicrobial potency against multidrug-resistant bacteria. | Eur J Pharm Sci | 2020

Evidence 15 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 5 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 5 | µg/mL | target cell: Sheep erythrocytes

Target

Target Cell Sheep erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Improving the biological activity of the antimicrobial peptide anoplin by membrane anchoring through a lipophilic amino acid derivative. | Bioorg Med Chem Lett | 2013

Evidence 16 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100-500 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 100-500 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Synthesis and biological activity of lipophilic analogs of the cationic antimicrobial active peptide anoplin. | J Pept Sci | 2016

Evidence 17 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 16.36 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 16.36 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 18 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 184.55 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 184.55 | µM | target cell: Human glomerular mesangial cells (GMC)

Target

Target Cell Human glomerular mesangial cells (GMC)

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 19 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 51.2 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 51.2 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 20 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 61.89 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 61.89 | µM | target cell: Human glomerular mesangial cells (GMC)

Target

Target Cell Human glomerular mesangial cells (GMC)

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 21 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 27.61 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 27.61 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 22 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 58.22 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 58.22 | µM | target cell: Human glomerular mesangial cells (GMC)

Target

Target Cell Human glomerular mesangial cells (GMC)

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 23 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 6.08 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 6.08 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 24 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 42.73 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 42.73 | µM | target cell: Human glomerular mesangial cells (GMC)

Target

Target Cell Human glomerular mesangial cells (GMC)

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 25 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 5.67 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 5.67 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 26 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 29.43 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 29.43 | µM | target cell: Human glomerular mesangial cells (GMC)

Target

Target Cell Human glomerular mesangial cells (GMC)

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 27 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 26.56 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 26.56 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 28 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 57.69 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 57.69 | µM | target cell: Human glomerular mesangial cells (GMC)

Target

Target Cell Human glomerular mesangial cells (GMC)

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 29 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 15.16 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 15.16 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 30 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 102.13 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 102.13 | µM | target cell: Human glomerular mesangial cells (GMC)

Target

Target Cell Human glomerular mesangial cells (GMC)

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 31 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 2.53 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 2.53 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 32 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 3.73 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 3.73 | µM | target cell: Human glomerular mesangial cells (GMC)

Target

Target Cell Human glomerular mesangial cells (GMC)

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 33 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 3.18 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 3.18 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 34 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 2.05 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 2.05 | µM | target cell: Human glomerular mesangial cells (GMC)

Target

Target Cell Human glomerular mesangial cells (GMC)

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 35 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 0.71 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 0.71 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 36 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 1.37 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 1.37 | µM | target cell: Human glomerular mesangial cells (GMC)

Target

Target Cell Human glomerular mesangial cells (GMC)

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 37 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 59.73 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 59.73 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 38 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 164.3 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 164.3 | µM | target cell: Human glomerular mesangial cells (GMC)

Target

Target Cell Human glomerular mesangial cells (GMC)

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 39 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 146.63 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 146.63 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 40 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 103.52 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 103.52 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 41 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 1.31 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 1.31 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 42 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 1.69 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 1.69 | µM | target cell: Human glomerular mesangial cells (GMC)

Target

Target Cell Human glomerular mesangial cells (GMC)

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 43 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 1.06 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 1.06 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 44 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 1.28 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 1.28 | µM | target cell: Human glomerular mesangial cells (GMC)

Target

Target Cell Human glomerular mesangial cells (GMC)

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 45 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 10.91 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 10.91 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 46 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 2.36 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 2.36 | µM | target cell: Human glomerular mesangial cells (GMC)

Target

Target Cell Human glomerular mesangial cells (GMC)

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 47 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 103.4 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 103.4 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 48 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 31.89 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 31.89 | µM | target cell: Human glomerular mesangial cells (GMC)

Target

Target Cell Human glomerular mesangial cells (GMC)

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 49 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 12.51 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 12.51 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 50 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 2.73 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 2.73 | µM | target cell: Human glomerular mesangial cells (GMC)

Target

Target Cell Human glomerular mesangial cells (GMC)

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 51 Activity

Activity

Activity Endpoint 10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 210.92 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10% Hemolysis | 210.92 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 52 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 116.32 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 116.32 | µM | target cell: Human glomerular mesangial cells (GMC)

Target

Target Cell Human glomerular mesangial cells (GMC)

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. | ACS Omega | 2021

Evidence 53 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Toxicity

Activity Measurement 1 %

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.25316570] 1% hemolysis at 12.5 µg/ml , 2% hemolysis at 25 µg/ml , 1% hemolysis at 50 µg/ml , 1.5% hemolysis at 100 µg/ml , 1.5% hemolysis at 200 µg/ml against mice red blood cells.##[Ref.27862650]3% hemolysis at 100µg/ml , 6% hemolysis at 200µg/ml , 10% hemolysis at 300µg/ml , 12% hemolysis at 500µg/ml against human red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Peptides. 2018 Jun 104:7-14.##J Pept Sci. 2014 Dec 20(12):945-51. doi: 10.1002/psc.2705.##J Pept Sci. 2016 Nov 22(11-12):731-736. doi: 10.1002/psc.2939.

Evidence 54 Hemolysis

Source & Reference

source APD_complete PD_Hemolysis

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.