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Peptide record

TPDB02353

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB02353
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP pep-lab Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GIMDTLKNLAKTAGKGALQSLLNKASCKLSGQC
Physicochemical Analysis
C142H252N42O45S3
REHFPWYV
L
3364.00
10.06
5
1
12
+4
3.83
-0.030
94.85
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
3.72
11
Residue Composition
number
4
A
0
R
2
N
1
D
2
C
0
E
2
Q
4
G
0
H
1
I
6
L
5
K
1
M
0
F
0
P
3
S
2
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 2 D: 1 C: 2 E: 0 Q: 2 G: 4 H: 0 I: 1 L: 6 K: 5 M: 1 F: 0 P: 0 S: 3 T: 2 W: 0 Y: 0 V: 0
Chemical Descriptors
33
C142H252N42O45S3
3364.00
10.06
+4
3.83
-0.030
Evidence Records 7 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
inhibition zone assay: Active against E. coli D21 (LC 0.5 uM), B. megaterium BmII (LC 0.2 uM), S. aureus Cowan 1 (LC 2.0 uM), C.albicans, and S.cerevisiae.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
inhibition zone assay: Active against E. coli D21 (LC 0.5 uM), B. megaterium BmII (LC 0.2 uM), S. aureus Cowan 1 (LC 2.0 uM), C.albicans, and S.cerevisiae.
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

inhibition zone assay: Active against E. coli D21 (LC 0.5 uM), B. megaterium BmII (LC 0.2 uM), S. aureus Cowan 1 (LC 2.0 uM), C.albicans, and S.cerevisiae.
Evidence 4 Activity

Activity

LC50
Hemolysis
100 µM
[Ref.8163497]LC50>100 µM against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
FEBS Lett. 1993 Jun 14 324(2):159-161.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 5 Activity

Activity

100% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
100% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel antimicrobial peptides from skin secretion of the European frog Rana esculenta. | FEBS Lett | 1993
Evidence 6 Activity

Activity

LC50
Toxicity
100 µM
Hemolytic
Hemolytic_activity: [Ref.8163497]LC50>100 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
FEBS Lett. 1993 Jun 14 324(2):159-161.
Evidence 7 Hemolysis

Activity

100 µM
LC50
[Ref.8163497]LC50>100 µM against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

APD_complete HemoPI PD_Hemolysis
FEBS Lett. 1993 Jun 14 324(2):159-161.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.