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Peptide record

TPDB02346

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB02346
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP 3.0 i2APP AI4AVP AVPpred-BWR DRAMP DRAVP 2.0 APD_complete Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GSIPACGESCFKGKCYTPGCSCSKYPLCAKN
Physicochemical Analysis
C135H212N36O42S6
RDQHMWV
C
3203.74
8.30
4
1
7
+3
2.79
-0.187
31.61
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
104.72
14
Residue Composition
number
2
A
0
R
1
N
0
D
6
C
1
E
0
Q
4
G
0
H
1
I
1
L
4
K
0
M
1
F
3
P
4
S
1
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 6 E: 1 Q: 0 G: 4 H: 0 I: 1 L: 1 K: 4 M: 0 F: 1 P: 3 S: 4 T: 1 W: 0 Y: 2 V: 0
Chemical Descriptors
31
C135H212N36O42S6
3203.74
8.30
+3
2.79
-0.187
Evidence Records 9 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

DRAMP

Other

It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 440 nM) and cytotoxicity (TC50 4.8 uM), therapeutic index (~11) (Ireland et al., 2008) . Active against nematode parasites of sheep (e.g. Haemonchus contortus or Trichostrongylus colubriformis): nematocidal.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

DRAMP CAFPdb Antifungipept

Other

It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 440 nM) and cytotoxicity (TC50 4.8 uM), therapeutic index (~11) (Ireland et al., 2008) . Active against nematode parasites of sheep (e.g. Haemonchus contortus or Trichostrongylus colubriformis): nematocidal.
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 440 nM) and cytotoxicity (TC50 4.8 uM), therapeutic index (~11) (Ireland et al., 2008) . Active against nematode parasites of sheep (e.g. Haemonchus contortus or Trichostrongylus colubriformis): nematocidal.
Evidence 4 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 440 nM) and cytotoxicity (TC50 4.8 uM), therapeutic index (~11) (Ireland et al., 2008) . Active against nematode parasites of sheep (e.g. Haemonchus contortus or Trichostrongylus colubriformis): nematocidal.
Evidence 5 Activity

Activity

% Hemolysis
Hemolysis
3 13 %
[Ref:16872274] It has 3% hemolytic activity at 1.0 µM and 13% hemolytic activity at 1.5 µM against human type A red blood cells

Target

human type A red blood cells

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Biochem J. 2006 Nov 15 400(1):1-12.##Biopolymers. 2008 90(1):51-60.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 6 Activity

Activity

11% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
11% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability. | Biochem J | 2006
Evidence 7 Activity

Activity

IC50
Toxicity
4.8 µM
Cytotoxic
IC50 | 4.8 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Cyclotides as natural anti-HIV agents | Biopolymers | 2008
Evidence 8 Activity

Activity

IC50
Toxicity
4800 nM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref:16872274] It has 3% hemolytic activity at 1.0 µM and 13% hemolytic activity at 1.5 µM against human type A red blood cells | Cytotoxicity: [Ref.18008336]CEM-SS cells:IC50=4800 nM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem J. 2006 Nov 15 400(1):1-12.##Biopolymers. 2008 90(1):51-60.
Evidence 9 Hemolysis

Activity

3 13 %
% Hemolysis
[Ref:16872274] It has 3% hemolytic activity at 1.0 µM and 13% hemolytic activity at 1.5 µM against human type A red blood cells
Hemolysis

Target

human type A red blood cells

Source & Reference

APD_complete PD_Hemolysis
Biochem J. 2006 Nov 15 400(1):1-12.##Biopolymers. 2008 90(1):51-60.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.