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Peptide record

TPDB02342

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB02342
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb i2APP APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
IFGAILPLALGALKNLIK
Physicochemical Analysis
C91H157N21O20
RDCEQHMSTWYV
L
1865.38
10.60
2
0
12
+2
-2.50
1.500
190.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
3
A
0
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
3
I
5
L
2
K
0
M
1
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 5 K: 2 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C91H157N21O20
1865.38
10.60
+2
-2.50
1.500
Evidence Records 29 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus (MIC 8 uM), P. aeruginosa (MIC 64 uM), E. coli ATCC 25992 (MIC 25-32 uM), K. pneumoniae ATCC 10031 (
Evidence 2 Activity

Activity

MIC
Antibacterial
64 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus (MIC 8 uM), P. aeruginosa (MIC 64 uM), E. coli ATCC 25992 (MIC 25-32 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), B. subtilis (
Evidence 3 Activity

Activity

MIC
Antibacterial
25-32 µM

Target

Escherichia coli ATCC 25992

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus (MIC 8 uM), P. aeruginosa (MIC 64 uM), E. coli ATCC 25992 (MIC 25-32 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), B. subtilis (MIC 8 uM), and E. faecalis (MIC 16
Evidence 4 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

Klebsiella pneumoniae ATCC 10031

Source & Reference

dbAMP DRAMP

Other

ainst S. aureus (MIC 8 uM), P. aeruginosa (MIC 64 uM), E. coli ATCC 25992 (MIC 25-32 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), B. subtilis (MIC 8 uM), and E. faecalis (MIC 16 uM). Virus: Also inhibit bovine and capr
Evidence 5 Activity

Activity

MIC
Antibacterial
8 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

a (MIC 64 uM), E. coli ATCC 25992 (MIC 25-32 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), B. subtilis (MIC 8 uM), and E. faecalis (MIC 16 uM). Virus: Also inhibit bovine and caprine herpesviruses, canin
Evidence 6 Activity

Activity

MIC
Antibacterial
16 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP DRAMP

Other

25992 (MIC 25-32 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), B. subtilis (MIC 8 uM), and E. faecalis (MIC 16 uM). Virus: Also inhibit bovine and caprine herpesviruses, canine distemper virus, bovine vir
Evidence 7 Activity

Activity

MIC
Antifungal
8 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus (MIC 8 uM), P. aeruginosa (MIC 64 uM), E. coli ATCC 25992 (MIC 25-32 uM), K. pneumoniae ATCC 10031 (
Evidence 8 Activity

Activity

MIC
Antifungal
64 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus (MIC 8 uM), P. aeruginosa (MIC 64 uM), E. coli ATCC 25992 (MIC 25-32 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), B. subtilis (
Evidence 9 Activity

Activity

MIC
Antifungal
25-32 µM

Target

Escherichia coli ATCC 25992

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus (MIC 8 uM), P. aeruginosa (MIC 64 uM), E. coli ATCC 25992 (MIC 25-32 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), B. subtilis (MIC 8 uM), and E. faecalis (MIC 16
Evidence 10 Activity

Activity

MIC
Antifungal
6.25 µM

Target

Klebsiella pneumoniae ATCC 10031

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ainst S. aureus (MIC 8 uM), P. aeruginosa (MIC 64 uM), E. coli ATCC 25992 (MIC 25-32 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), B. subtilis (MIC 8 uM), and E. faecalis (MIC 16 uM). Virus: Also inhibit bovine and capr
Evidence 11 Activity

Activity

MIC
Antifungal
8 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

a (MIC 64 uM), E. coli ATCC 25992 (MIC 25-32 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), B. subtilis (MIC 8 uM), and E. faecalis (MIC 16 uM). Virus: Also inhibit bovine and caprine herpesviruses, canin
Evidence 12 Activity

Activity

MIC
Antifungal
16 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

25992 (MIC 25-32 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), B. subtilis (MIC 8 uM), and E. faecalis (MIC 16 uM). Virus: Also inhibit bovine and caprine herpesviruses, canine distemper virus, bovine vir
Evidence 13 Activity

Activity

MIC
Antiparasitic
8 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against S. aureus (MIC 8 uM), P. aeruginosa (MIC 64 uM), E. coli ATCC 25992 (MIC 25-32 uM), K. pneumoniae ATCC 10031 (
Evidence 14 Activity

Activity

MIC
Antiparasitic
64 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

Active against S. aureus (MIC 8 uM), P. aeruginosa (MIC 64 uM), E. coli ATCC 25992 (MIC 25-32 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), B. subtilis (
Evidence 15 Activity

Activity

MIC
Antiparasitic
25-32 µM

Target

Escherichia coli ATCC 25992

Source & Reference

DRAMP

Other

Active against S. aureus (MIC 8 uM), P. aeruginosa (MIC 64 uM), E. coli ATCC 25992 (MIC 25-32 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), B. subtilis (MIC 8 uM), and E. faecalis (MIC 16
Evidence 16 Activity

Activity

MIC
Antiparasitic
6.25 µM

Target

Klebsiella pneumoniae ATCC 10031

Source & Reference

DRAMP

Other

ainst S. aureus (MIC 8 uM), P. aeruginosa (MIC 64 uM), E. coli ATCC 25992 (MIC 25-32 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), B. subtilis (MIC 8 uM), and E. faecalis (MIC 16 uM). Virus: Also inhibit bovine and capr
Evidence 17 Activity

Activity

MIC
Antiparasitic
8 µM

Target

B. subtilis

Source & Reference

DRAMP

Other

a (MIC 64 uM), E. coli ATCC 25992 (MIC 25-32 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), B. subtilis (MIC 8 uM), and E. faecalis (MIC 16 uM). Virus: Also inhibit bovine and caprine herpesviruses, canin
Evidence 18 Activity

Activity

MIC
Antiparasitic
16 µM

Target

Enterococcus faecalis

Source & Reference

DRAMP

Other

25992 (MIC 25-32 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), B. subtilis (MIC 8 uM), and E. faecalis (MIC 16 uM). Virus: Also inhibit bovine and caprine herpesviruses, canine distemper virus, bovine vir
Evidence 19 Activity

Activity

MIC
Antiviral
8 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against S. aureus (MIC 8 uM), P. aeruginosa (MIC 64 uM), E. coli ATCC 25992 (MIC 25-32 uM), K. pneumoniae ATCC 10031 (
Evidence 20 Activity

Activity

MIC
Antiviral
64 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

Active against S. aureus (MIC 8 uM), P. aeruginosa (MIC 64 uM), E. coli ATCC 25992 (MIC 25-32 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), B. subtilis (
Evidence 21 Activity

Activity

MIC
Antiviral
25-32 µM

Target

Escherichia coli ATCC 25992

Source & Reference

DRAMP

Other

Active against S. aureus (MIC 8 uM), P. aeruginosa (MIC 64 uM), E. coli ATCC 25992 (MIC 25-32 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), B. subtilis (MIC 8 uM), and E. faecalis (MIC 16
Evidence 22 Activity

Activity

MIC
Antiviral
6.25 µM

Target

Klebsiella pneumoniae ATCC 10031

Source & Reference

DRAMP

Other

ainst S. aureus (MIC 8 uM), P. aeruginosa (MIC 64 uM), E. coli ATCC 25992 (MIC 25-32 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), B. subtilis (MIC 8 uM), and E. faecalis (MIC 16 uM). Virus: Also inhibit bovine and capr
Evidence 23 Activity

Activity

MIC
Antiviral
8 µM

Target

B. subtilis

Source & Reference

DRAMP

Other

a (MIC 64 uM), E. coli ATCC 25992 (MIC 25-32 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), B. subtilis (MIC 8 uM), and E. faecalis (MIC 16 uM). Virus: Also inhibit bovine and caprine herpesviruses, canin
Evidence 24 Activity

Activity

MIC
Antiviral
16 µM

Target

Enterococcus faecalis

Source & Reference

DRAMP

Other

25992 (MIC 25-32 uM), K. pneumoniae ATCC 10031 (MIC 6.25 uM), B. subtilis (MIC 8 uM), and E. faecalis (MIC 16 uM). Virus: Also inhibit bovine and caprine herpesviruses, canine distemper virus, bovine vir
Evidence 25 Activity

Activity

HC50
Hemolysis
18 µM
[Ref.19056441]HC50=18 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Peptides. 2009 Feb 30(2):291-296.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 26 Activity

Activity

50% Hemolysis
Toxicity
18 µM
Hemolytic Cytotoxic
50% Hemolysis | 18 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Hylin a1, the first cytolytic peptide isolated from the arboreal South American frog Hypsiboas albopunctatus ("spotted treefrog"). | Peptides | 2009
Evidence 27 Activity

Activity

94% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
94% Hemolysis | 50 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Bactericidal activities and Action mechanism of the Novel Antimicrobial Peptide Hylin a1 and its analog peptides against Acinetobacter baumannii infection. | Eur J Pharm Sci | 2022
Evidence 28 Activity

Activity

HC50
Toxicity
18 µM
Hemolytic
Hemolytic_activity: [Ref.19056441]HC50=18 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2009 Feb 30(2):291-296.
Evidence 29 Hemolysis

Activity

18 µM
HC50
[Ref.19056441]HC50=18 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Peptides. 2009 Feb 30(2):291-296.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.