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Peptide record

TPDB02341

Antibacterial Anticancer Hemolysis Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB02341
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
RFGRFLRKIRRFRPK
Physicochemical Analysis
C94H157N35O16
ANDCEQHMSTWYV
R
2033.51
13.10
8
0
5
+8
3.04
-1.340
52.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
1
L
2
K
0
M
3
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 1 K: 2 M: 0 F: 3 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
15
C94H157N35O16
2033.51
13.10
+8
3.04
-1.340
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

S. typhimurium NCTC 74

Source & Reference

NA

Other

active against Gram- E. coli O175:H7 (MIC 64 ug/ml), S. typhimurium NCTC 74 (MIC 8 ug/ml), and Gram+ S.aureus ATCC 9155 (MIC > 128 ug/ml).
Evidence 2 Activity

Activity

10% Hemolysis
Toxicity
2.78 µM
Hemolytic Cytotoxic
10% Hemolysis | 2.78 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Hybridization With Insect Cecropin A (1-8) Improve the Stability and Selectivity of Naturally Occurring Peptides. | Int J Mol Sci | 2020
Evidence 3 Activity

Activity

60% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
60% Hemolysis | 256 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Hybridization With Insect Cecropin A (1-8) Improve the Stability and Selectivity of Naturally Occurring Peptides. | Int J Mol Sci | 2020
Evidence 4 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Chicken macrophages HD-11

Target

Chicken macrophages HD-11

Source & Reference

NA
DBAASP
Avian antimicrobial peptides: in vitro and in ovo characterization and protection from early chick mortality caused by yolk sac infection. | Sci Rep | 2021
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
97.76 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 97.76 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design, characterization and structure-function analysis of novel antimicrobial peptides based on the N-terminal CATH-2 fragment. | Sci Rep | 2022
Evidence 6 Activity

Activity

15% Cell death
Toxicity
1978.47 µg/mL
Cytotoxic
15% Cell death | 1978.47 | µg/mL | target cell: Murine macrophages

Target

Murine macrophages

Source & Reference

NA
DBAASP
Design, characterization and structure-function analysis of novel antimicrobial peptides based on the N-terminal CATH-2 fragment. | Sci Rep | 2022
Evidence 7 Activity

Activity

12% Hemolysis
Toxicity
64 µg/mL
Hemolytic Cytotoxic
12% Hemolysis | 64 | µg/mL | target cell: Chicken erythrocytes

Target

Chicken erythrocytes

Source & Reference

NA
DBAASP
CATH-2-derived antimicrobial peptide inhibits multidrug-resistant Escherichia coli infection in chickens | Front Cell Infect Microbiol | 2024
Evidence 8 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Chicken kidney cells

Target

Chicken kidney cells

Source & Reference

NA
DBAASP
CATH-2-derived antimicrobial peptide inhibits multidrug-resistant Escherichia coli infection in chickens | Front Cell Infect Microbiol | 2024
Evidence 9 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis