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Peptide record

TPDB02338

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB02338
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLPIVGKLLSGLL
Physicochemical Analysis
C68H116N14O15
ARNDCEQHMTWY
L
1369.75
10.10
1
0
8
+1
-2.58
1.800
202.31
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
1
I
5
L
1
K
0
M
1
F
1
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 5 K: 1 M: 0 F: 1 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
13
C68H116N14O15
1369.75
10.10
+1
-2.58
1.800
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
100-110 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus (MIC 100-110 uM). Also active against B. dendrobatidis (Table 1, Rollins-Smith, BBA 2009 1788:1593-1599).
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP

Other

in North American frog Rana cascadae and named as temporin-1CSa and found active against S. aureus ATCC 25923 (MIC 8 uM) (Conlon et al 2007 Peptides 28: 1268-1274). It is also found in the mountain yellow-legge
Evidence 3 Activity

Activity

MIC
Antifungal
100-110 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus (MIC 100-110 uM). Also active against B. dendrobatidis (Table 1, Rollins-Smith, BBA 2009 1788:1593-1599).
Evidence 4 Activity

Activity

MIC
Antifungal
8 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

in North American frog Rana cascadae and named as temporin-1CSa and found active against S. aureus ATCC 25923 (MIC 8 uM) (Conlon et al 2007 Peptides 28: 1268-1274). It is also found in the mountain yellow-legge
Evidence 5 Activity

Activity

MIC
Antiparasitic
100-110 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against S. aureus (MIC 100-110 uM). Also active against B. dendrobatidis (Table 1, Rollins-Smith, BBA 2009 1788:1593-1599).
Evidence 6 Activity

Activity

MIC
Antiparasitic
8 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

DRAMP

Other

in North American frog Rana cascadae and named as temporin-1CSa and found active against S. aureus ATCC 25923 (MIC 8 uM) (Conlon et al 2007 Peptides 28: 1268-1274). It is also found in the mountain yellow-legge
Evidence 7 Activity

Activity

LC50
Hemolysis
75 µM
[Ref.17451843] LC50 = 75 µM against human erythrocytes.

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Eur J Biochem. 2000 Feb 267(3):894-900.##Peptides 2007 28: 1268-1274.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
75 µM
Hemolytic Cytotoxic
50% Hemolysis | 75 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptide defenses of the Cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group. | Peptides | 2007
Evidence 9 Activity

Activity

LC50
Toxicity
75 µM
Hemolytic
Hemolytic_activity: [Ref.17451843] LC50 = 75 µM against human erythrocytes.

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Biochem. 2000 Feb 267(3):894-900.##Peptides 2007 28: 1268-1274.
Evidence 10 Hemolysis

Activity

75 µM
LC50
[Ref.17451843] LC50 = 75 µM against human erythrocytes.
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete HemoPI PD_Hemolysis
Eur J Biochem. 2000 Feb 267(3):894-900.##Peptides 2007 28: 1268-1274.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.