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Peptide record

TPDB02326

Phylloseptin Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard

32 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB02326

Peptide_Name

Phylloseptin

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab AFP-GFuse Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 32-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GLWSKIKEAAKAAGKAALNAVTGLVNQGDQPS

FASTA

>TPDB02326|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Hemolysis;Toxicity|length=32
GLWSKIKEAAKAAGKAALNAVTGLVNQGDQPS

Formula C140H233N41O44

Absent Amino Acids RCHMFY

Common Amino Acids A

Mass 3194.64

PI 10.16

Basic Residues 4

Acidic Residues 2

Hydrophobic Residues 14

Net Charge +2

Boman Index 5.21

Hydrophobicity -0.191

Aliphatic Index 88.75

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 172.16

Polar Residues 7

number

Amino Acid Distribution

A: 7 R: 0 N: 2 D: 1 C: 0 E: 1 Q: 2 G: 4 H: 0 I: 1 L: 3 K: 4 M: 0 F: 0 P: 1 S: 2 T: 1 W: 1 Y: 0 V: 2

Length

Formula

C140H233N41O44

Mass

3194.64

10.16

Net Charge

Boman Index

5.21

Hydrophobicity

-0.191

C_terminal_Modification

Free

Chirality

Linear_or_Cyclic

Not Available

N_terminal_Modification

Free

Nature

Anticancer

Origin

Hylomantis lemur (Hylidae: Phyllomedusinae

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Dermaseptin-L1 was active against the Gram-negative bacterium E. coli (MIC 8 uM) but inactive against the Gram-positive bacterium S.aureus. This peptide inhibited growth

Evidence 2 Activity

Activity

Activity Raw

Not Available

Detail Source Activity Anticancer

Target

Cancer Type Colorectal Cancer

Cell Line Not Available

Tissue Affected Not Available

Assay & Model

Assay Not Available

Testing Time Not Available

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2007

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Dermaseptin-L1 was active against the Gram-negative bacterium E. coli (MIC 8 uM) but inactive against the Gram-positive bacterium S.aureus. This peptide inhibited growth

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Dermaseptin-L1 was active against the Gram-negative bacterium E. coli (MIC 8 uM) but inactive against the Gram-positive bacterium S.aureus. This peptide inhibited growth

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 8 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

Dermaseptin-L1 was active against the Gram-negative bacterium E. coli (MIC 8 uM) but inactive against the Gram-positive bacterium S.aureus. This peptide inhibited growth

Evidence 6 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 200 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Peptides with differential cytolytic activity from skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae). | Toxicon | 2007

Evidence 7 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 45 µM

Toxicity Type Cytotoxic

Toxicity Raw

Cytotoxicity: [Ref.17561225]Displayed cytotoxic against HepG2 cells(LC50=45µM)

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Toxicon. 2007 Sep 15 50(4):498-506.

Evidence 8 Hemolysis

Source & Reference

source APD_complete HemoPI PD_Hemolysis

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.