TPDB

3D PDB MODEL

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TPDB ID TPDB02297

Peptide_Name

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

ACE inhibitors Antibacterial Antihypertensive Antioxidant Bitter Neuropeptide iDPPIV

Activity_category_statistics

Anti-infective peptides Cardiometabolic peptides Neuroactive peptides Food sensory peptides Functional / health-promoting peptides

Database_Source

Peptipedia AHTPDB AODB Multi-AOP Tastepeptides-Meta iDPPIV

Sequence_Type

standard

Has_Modification No

Description A 2-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Antihypertensive, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AODB, and other sources, with an available 3D structural model.

Sequence

YY

FASTA

>TPDB02297|ACE inhibitors;Antibacterial;Antihypertensive;Antioxidant;Bitter;Neuropeptide;iDPPIV|length=2
YY

Formula C18H20N2O5

Absent Amino Acids ARNDCEQGHILKMFPSTWV

Common Amino Acids Y

Mass 344.37

PI 5.88

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 2

Net Charge -0

Boman Index -1.88

Hydrophobicity -1.300

Aliphatic Index 0.00

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 2980

Absorbance 280nm 865.36

Polar Residues 2

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

0

F

0

P

0

S

0

T

0

W

2

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 2 V: 0

Length

2

Formula

C18H20N2O5

Mass

344.37

PI

5.88

Net Charge

-0

Boman Index

-1.88

Hydrophobicity

-1.300

Chemical_Mass

344.3610

Monoisotopic_Mass

344.1367

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 180.00 µM

Function Inhibitor of angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Lafarga T, Aluko RE, Rai DK, O'Connor P, Hayes M.

Title

Identification of bioactive peptides from a papain hydrolysate of bovine serum albumin and assessment of an antihypertensive effect in spontaneously hypertensive rats. Food Res Int. 81, 91-99, 2016

Year 2016

Literature Source Journal

Other

Number of Residues 2

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O InChI= 1S/C18H20N2O5/c19-15(9-11-1-5-13(21)6-2-11)17(23)20-16(18(24)25)10-12-3-7-14(22)8-4-12/h1-8,15-16,21-22H,9-10,19H2,(H,20,23)(H,24,25)/t15-,16-/m0/s1 InChIKey: JAQGKXUEKGKTKX-HOTGVXAUSA-N Inhibitor of Dipeptidyl peptidase IV (DPP IV) (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8948) Inhibitor of Dipeptidyl peptidase III (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9476) the BRENDA database Inhibitor of tyrosyl tRNA synthetase (EC 6.1.1.1) from Staphylococcus aureus according to the ChEMBL database the PubChem database Inhibitor of renin (EC 3.4.23.15) (MEROPS ID: A01.007) according to the BRENDA database Inhibitor of tubulin-tyrosine ligase (EC 6.3.2.25) according to the BRENDA database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID: 33)

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 180.00 µM

Function Inhibitor of angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Lafarga T, Aluko RE, Rai DK, O'Connor P, Hayes M.

Title

Identification of bioactive peptides from a papain hydrolysate of bovine serum albumin and assessment of an antihypertensive effect in spontaneously hypertensive rats. Food Res Int. 81, 91-99, 2016

Year 2016

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 2

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O InChI= 1S/C18H20N2O5/c19-15(9-11-1-5-13(21)6-2-11)17(23)20-16(18(24)25)10-12-3-7-14(22)8-4-12/h1-8,15-16,21-22H,9-10,19H2,(H,20,23)(H,24,25)/t15-,16-/m0/s1 InChIKey: JAQGKXUEKGKTKX-HOTGVXAUSA-N Inhibitor of Dipeptidyl peptidase IV (DPP IV) (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8948) Inhibitor of Dipeptidyl peptidase III (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9476) the BRENDA database Inhibitor of tyrosyl tRNA synthetase (EC 6.1.1.1) from Staphylococcus aureus according to the ChEMBL database the PubChem database Inhibitor of renin (EC 3.4.23.15) (MEROPS ID: A01.007) according to the BRENDA database Inhibitor of tubulin-tyrosine ligase (EC 6.3.2.25) according to the BRENDA database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID: 33)

Evidence 3 Activity

Activity

Main Bioactivity Antioxidative activity

Detail Source Activity Antioxidant

Source & Reference

Database Source AODB

Source DFBP

Evidence 4 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 0.00 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.

Title Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015

Year 2015

Literature Source Journal

Other

Number of Residues 2

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O InChI=1S/C18H20N2O5/c19-15(9-11-1-5-13(21)6-2-11)17(23)20-16(18(24)25)10-12-3-7-14(22)8-4-12/h1-8,15-16,21-22H,9-10,19H2,(H,20,23)(H,24,25)/t15-,16-/m0/s1 InChIKey: JAQGKXUEKGKTKX-HOTGVXAUSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02.001) according to the AHTPDB database the BIOPEP-UWM database of bioactive peptides (ID 9946) the EROP-Moscow database Inhibitor of Dipeptidyl peptidase III (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9476) the BRENDA database Inhibitor of tyrosyl tRNA synthetase (EC 6.1.1.1) from Staphylococcus aureus according to the ChEMBL database the PubChem database Inhibitor of renin (EC 3.4.23.15) (MEROPS ID: A01.007) according to the BRENDA database Inhibitor of tubulin-tyrosine ligase (EC 6.3.2.25) according to the BRENDA database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID: 33) Information concerning Dipeptidyl peptidase IV (DPP IV) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: MS09.003)

Number_of_Residues

2