Back to search

Peptide record

TPDB02259

ACE inhibitor ACE inhibitors Antihypertensive Antioxidant standard
7 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB02259
ACE inhibitor
ACE inhibitors Antihypertensive Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
pep-lab Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB AoXpDb Multi-AOP
standard
No
A 7-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Antioxidant) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
YQKFPQY
Physicochemical Analysis
C48H64N10O12
ARNDCEGHILMSTWV
QY
973.10
9.56
1
0
3
+1
-0.41
-1.757
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
2980
306.24
4
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
0
I
0
L
1
K
0
M
1
F
1
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
7
C48H64N10O12
973.10
9.56
+1
-0.41
-1.757
973.0790
972.4690
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
20.08 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Contreras M. M., Carrón R., Montero M. J., Ramos M., Recio I.
Novel casein-derived peptides with antihypertensive activity. Int. Dairy J. 2009 19: 566-573.
2009
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(O)=O InChI=1S/C48H64N10O12/c49-23-5-4-9-34(54-44(65)35(19-21-40(51)61)53-42(63)33(50)25-29-11-15-31(59)16-12-29)43(64)56-37(26-28-7-2-1-3-8-28)47(68)58-24-6-10-39(58)46(67)55-36(20-22-41(52)62)45(66)57-38(48(69)70)27-30-13-17-32(60)18-14-30/h1-3,7-8,11-18,33-39,59-60H,4-6,9-10,19-27,49-50H2,(H2,51,61)(H2,52,62)(H,53,63)(H,54,65)(H,55,67)(H,56,64)(H,57,66)(H,69,70)/t33-,34-,35-,36-,37-,38-,39-/m0/s1 InChIKey: TZXMOJGCTZFVLR-ZTYVOHGWSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9261) the MBPDB database
Evidence 2 Activity

Activity

IC50
Antihypertensive
20.08 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Contreras M. M., Carrón R., Montero M. J., Ramos M., Recio I.
Novel casein-derived peptides with antihypertensive activity. Int. Dairy J. 2009 19: 566-573.
2009
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
7
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(O)=O InChI=1S/C48H64N10O12/c49-23-5-4-9-34(54-44(65)35(19-21-40(51)61)53-42(63)33(50)25-29-11-15-31(59)16-12-29)43(64)56-37(26-28-7-2-1-3-8-28)47(68)58-24-6-10-39(58)46(67)55-36(20-22-41(52)62)45(66)57-38(48(69)70)27-30-13-17-32(60)18-14-30/h1-3,7-8,11-18,33-39,59-60H,4-6,9-10,19-27,49-50H2,(H2,51,61)(H2,52,62)(H,53,63)(H,54,65)(H,55,67)(H,56,64)(H,57,66)(H,69,70)/t33-,34-,35-,36-,37-,38-,39-/m0/s1 InChIKey: TZXMOJGCTZFVLR-ZTYVOHGWSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9261) the MBPDB database
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB AoXpDb
DFBP
Additional Detail Fields 1 fields
7