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Peptide record

TPDB02244

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antihypertensive Antioxidant Neuropeptide iDPPIV standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB02244
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antihypertensive Antioxidant Neuropeptide iDPPIV
Cardiometabolic peptides Neuroactive peptides Functional / health-promoting peptides
FermFooDB Peptipedia AHTPDB AHTpin AODB Multi-AOP iDPPIV
standard
No
A 4-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Antioxidant, and other sources) peptide sequence curated from FermFooDB, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
YPYY
Physicochemical Analysis
C32H36N4O8
ARNDCEQGHILKMFSTWV
Y
604.66
5.84
0
0
3
-0
-2.37
-1.375
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
4470
739.26
3
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
3
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 3 V: 0
Chemical Descriptors
4
C32H36N4O8
604.66
5.84
-0
-2.37
-1.375
604.6488
604.2524
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
90.90 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Tsai J.-S., Chen T.-J., Pan B. S., Gong S.-D., Chung M.-Y.
Antihypertensive effect of bioactive peptides produced by protease-facilitated lactic acid fermentation of milk. Food Chem., 106, 552-558, 2008
2008
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(O)=O InChI=1S/C32H36N4O8/c33-25(16-19-3-9-22(37)10-4-19)31(42)36-15-1-2-28(36)30(41)34-26(17-20-5-11-23(38)12-6-20)29(40)35-27(32(43)44)18-21-7-13-24(39)14-8-21/h3-14,25-28,37-39H,1-2,15-18,33H2,(H,34,41)(H,35,40)(H,43,44)/t25-,26-,27-,28-/m0/s1 InChIKey=GINKSLAFZJESRI-LJWNLINESA-N Opioid antagonist according to the BIOPEP-UWM database of bioactive peptides (ID 3218) the EROP-Moscow database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8615) Ileum contracting peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9725)
Evidence 2 Activity

Activity

IC50
Antihypertensive
90.90 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Tsai J.-S., Chen T.-J., Pan B. S., Gong S.-D., Chung M.-Y.
Antihypertensive effect of bioactive peptides produced by protease-facilitated lactic acid fermentation of milk. Food Chem., 106, 552-558, 2008
2008
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
4
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(O)=O InChI=1S/C32H36N4O8/c33-25(16-19-3-9-22(37)10-4-19)31(42)36-15-1-2-28(36)30(41)34-26(17-20-5-11-23(38)12-6-20)29(40)35-27(32(43)44)18-21-7-13-24(39)14-8-21/h3-14,25-28,37-39H,1-2,15-18,33H2,(H,34,41)(H,35,40)(H,43,44)/t25-,26-,27-,28-/m0/s1 InChIKey=GINKSLAFZJESRI-LJWNLINESA-N Opioid antagonist according to the BIOPEP-UWM database of bioactive peptides (ID 3218) the EROP-Moscow database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8615) Ileum contracting peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9725)
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB FermFooDB
DFBP
Evidence 4 Activity

Activity

EC50
iDPPIV
149.40 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Nongonierma A. B., FitzGerald R. J.
Susceptibility of milk protein-derived peptides to dipeptidyl peptidase IV (DPP-IV) hydrolysis. Food Chemistry 145, 845-852, 2014
2014
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(O)=O InChI=1S/C32H36N4O8/c33-25(16-19-3-9-22(37)10-4-19)31(42)36-15-1-2-28(36)30(41)34-26(17-20-5-11-23(38)12-6-20)29(40)35-27(32(43)44)18-21-7-13-24(39)14-8-21/h3-14,25-28,37-39H,1-2,15-18,33H2,(H,34,41)(H,35,40)(H,43,44)/t25-,26-,27-,28-/m0/s1 InChIKey=GINKSLAFZJESRI-LJWNLINESA-N Opioid antagonist according to the BIOPEP-UWM database of bioactive peptides (ID 3218) Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BIOPEP-UWM database of bioactive peptides (ID 9724) the MBPDB database Ileum contracting peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9725)
Additional Detail Fields 1 fields
4