Back to search

Peptide record

TPDB02241

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Antibacterial Antihypertensive Antioxidant Neuropeptide iDPPIV standard
6 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB02241
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
Antibacterial Antihypertensive Antioxidant Neuropeptide iDPPIV
Anti-infective peptides Cardiometabolic peptides Neuroactive peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AODB AoXpDb iDPPIV
standard
No
A 6-aa standard natural multi-activity (Antibacterial, Antihypertensive, Antioxidant, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
YPVEPF
Physicochemical Analysis
C38H50N6O10
ARNDCQGHILKMSTW
P
750.85
3.29
0
1
3
-1
0.92
-0.167
48.33
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
198.44
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
2
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
6
C38H50N6O10
750.85
3.29
-1
0.92
-0.167
750.8358
750.3576
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

inhibition zone: Active against B. thuringiensis USDA HD22 (<30 mm), B. cereus ATCC 11778 BC45 (<30 mm), and L. monocytogenes (<10 mm). Updated 6/2018 7/2021.
Evidence 2 Activity

Activity

IC50
iDPPIV
124.70 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Nongonierma A. B., FitzGerald R. J.
Structure activity relationship modelling of milk protein-derived peptides with dipeptidyl peptidase IV (DPP-IV) inhibitory activity. Peptides, 2016, 79, 1-7.
2016
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(O)=O InChI=1S/C38H50N6O10/c1-22(2)32(42-34(49)30-11-6-18-43(30)36(51)26(39)20-24-12-14-25(45)15-13-24)35(50)40-27(16-17-31(46)47)37(52)44-19-7-10-29(44)33(48)41-28(38(53)54)21-23-8-4-3-5-9-23/h3-5,8-9,12-15,22,26-30,32,45H,6-7,10-11,16-21,39H2,1-2H3,(H,40,50)(H,41,48)(H,42,49)(H,46,47)(H,53,54)/t26-,27-,28-,29-,30-,32-/m0/s1 InChIKey: XHQLRBCHRWBONA-RUAREOIKSA-N Opioid peptide according to the the BIOPEP-UWM database of bioactive peptides (ID 9852) the EROP-Moscow database the MBPDB database Peptide stimulating mucin synthesis according to the BIOPEP-UWM database of bioactive peptides (ID 9851) the MBPDB database Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10100)
Additional Detail Fields 1 fields
6