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Peptide record

TPDB02234

Rubiscolin-6 ACE inhibitor ACE inhibitors Antihypertensive Antioxidant standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB02234
Rubiscolin-6 ACE inhibitor
ACE inhibitors Antihypertensive Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AODB AoXpDb Multi-AOP
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Antioxidant) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
YPLDLF
Physicochemical Analysis
C39H54N6O10
ARNCEQGHIKMSTWV
L
766.89
3.10
0
1
4
-1
-1.51
0.667
130.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
194.29
1
Residue Composition
number
0
A
0
R
0
N
1
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
0
K
0
M
1
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
6
C39H54N6O10
766.89
3.10
-1
-1.51
0.667
766.8781
766.3888
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
24.40 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Wang W., Gonzalez de Mejia E.
A new frontier in soy bioactive peptides that may prevent age-related chronic diseases. Comp. Rev. Food Sci. Food Safety, 2005, 4, 63 -77.
2005
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O InChI=1S/C39H54N6O10/c1-22(2)17-28(35(50)44-31(39(54)55)20-24-9-6-5-7-10-24)41-36(51)30(21-33(47)48)42-34(49)29(18-23(3)4)43-37(52)32-11-8-16-45(32)38(53)27(40)19-25-12-14-26(46)15-13-25/h5-7,9-10,12-15,22-23,27-32,46H,8,11,16-21,40H2,1-4H3,(H,41,51)(H,42,49)(H,43,52)(H,44,50)(H,47,48)(H,54,55)/t27-,28-,29-,30-,31-,32-/m0/s1 InChIKey=WNALJHAPDVEDJB-JNRWAQIZSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10048) Opioid peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9276), the PlantPepDB database Food intake regulating peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10131)
Evidence 2 Activity

Activity

IC50
Antihypertensive
24.40 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Wang W., Gonzalez de Mejia E.
A new frontier in soy bioactive peptides that may prevent age-related chronic diseases. Comp. Rev. Food Sci. Food Safety, 2005, 4, 63 -77.
2005
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O InChI=1S/C39H54N6O10/c1-22(2)17-28(35(50)44-31(39(54)55)20-24-9-6-5-7-10-24)41-36(51)30(21-33(47)48)42-34(49)29(18-23(3)4)43-37(52)32-11-8-16-45(32)38(53)27(40)19-25-12-14-26(46)15-13-25/h5-7,9-10,12-15,22-23,27-32,46H,8,11,16-21,40H2,1-4H3,(H,41,51)(H,42,49)(H,43,52)(H,44,50)(H,47,48)(H,54,55)/t27-,28-,29-,30-,31-,32-/m0/s1 InChIKey=WNALJHAPDVEDJB-JNRWAQIZSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10048) Opioid peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9276), the PlantPepDB database Food intake regulating peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10131)
Additional Detail Fields 1 fields
6