TPDB

3D PDB MODEL

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TPDB ID TPDB02228

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antioxidant Neuropeptide

Activity_category_statistics

Cardiometabolic peptides Neuroactive peptides Functional / health-promoting peptides

Database_Source

Peptipedia AODB AoXpDb

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural multi-activity (ACE inhibitors, Antioxidant, and Neuropeptide) peptide sequence curated from Peptipedia, AODB, and AoXpDb, with an available 3D structural model.

Sequence

YPFVEP

FASTA

>TPDB02228|ACE inhibitors;Antioxidant;Neuropeptide|length=6
YPFVEP

Formula C38H50N6O10

Absent Amino Acids ARNDCQGHILKMSTW

Common Amino Acids P

Mass 750.85

PI 3.29

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 3

Net Charge -1

Boman Index 0.92

Hydrophobicity -0.167

Aliphatic Index 48.33

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 198.44

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

1

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

1

F

2

P

0

S

0

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 1 V: 1

Length

6

Formula

C38H50N6O10

Mass

750.85

PI

3.29

Net Charge

-1

Boman Index

0.92

Hydrophobicity

-0.167

Chemical_Mass

750.8358

Monoisotopic_Mass

750.3576

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 7.48 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Amigo L., Martínez-Maqueda D., Hernández-Ledesma B.

Title In silico and in vitro analysis of multifunctionality of animal food-derived peptides. Foods, 9, 991, 2020

Year 2020

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C38H50N6O10/c1-22(2)32(35(50)40-27(16-17-31(46)47)37(52)44-19-7-11-30(44)38(53)54)42-33(48)28(21-23-8-4-3-5-9-23)41-34(49)29-10-6-18-43(29)36(51)26(39)20-24-12-14-25(45)15-13-24/h3-5,8-9,12-15,22,26-30,32,45H,6-7,10-11,16-21,39H2,1-2H3,(H,40,50)(H,41,49)(H,42,48)(H,46,47)(H,53,54)/t26-,27-,28-,29-,30-,32-/m0/s1 InChIKey=WUHXJZCLFYNVBB-RUAREOIKSA-N Opioid agonist according to the BIOPEP-UWM database of bioactive peptides (ID 2863) the EROP-Moscow database the MBPDB database Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10083), the MBPDB database

Number_of_Residues

6