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Peptide record

TPDB02226

ACE inhibitor (fr.60-68 of bovine beta-casein) Dipeptidyl peptidase IV (DPPIV) inhibitor ACE inhibitors Antihypertensive Antioxidant Bitter Neuropeptide iDPPIV standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB02226
ACE inhibitor (fr.60-68 of bovine beta-casein) Dipeptidyl peptidase IV (DPPIV) inhibitor
ACE inhibitors Antihypertensive Antioxidant Bitter Neuropeptide iDPPIV
Cardiometabolic peptides Neuroactive peptides Food sensory peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AODB AoXpDb FermFooDB Multi-AOP Tastepeptides-Meta iDPPIV
standard
No
A 9-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Antioxidant, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
YPFPGPIPN
Physicochemical Analysis
C50H68N10O12
ARDCEQHLKMSTWV
P
1001.15
5.94
0
0
3
-0
-0.15
-0.478
43.33
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
148.83
2
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
0
L
0
K
0
M
1
F
4
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 0 M: 0 F: 1 P: 4 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
9
C50H68N10O12
1001.15
5.94
-0
-0.15
-0.478
1001.1320
1000.5002
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
15.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
FitzGerald R. J., Murray B. A., Walsh D. J.
Hypotensive peptides from milk proteins. http://www.jn.nutrition.org
2004
www sites

Other

9
Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Peptide found in yoghurt: Farvin K. H. S., Baron C. P., Nielsen N. S., Jacobsen C., 2010, Antioxidant activity of yoghurt peptides: part 2 – Characterisation of peptide fractions. Food Chem., 123, 1090-1097
Evidence 2 Activity

Activity

IC50
Antihypertensive
15.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
FitzGerald R. J., Murray B. A., Walsh D. J.
Hypotensive peptides from milk proteins. http://www.jn.nutrition.org
2004
www sites

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
9
Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Peptide found in yoghurt: Farvin K. H. S., Baron C. P., Nielsen N. S., Jacobsen C., 2010, Antioxidant activity of yoghurt peptides: part 2 – Characterisation of peptide fractions. Food Chem., 123, 1090-1097
Evidence 3 Activity

Activity

IC50
iDPPIV
670.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Uenishi H., Kabuki T., Seto Y., Serizawa A., Nakajima H.
Isolation and identification of casein-derived dipeptidyl-peptidase 4 (DPP-4)-inhibitory peptide LPQNIPPL from gouda-type cheese and its effect on plasma glucose in rats. Int. Dairy J., 22, 24-30, 2012
2012
Journal

Other

9
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N4[C@@H](CCC4)C(=O)NCC(=O)N5[C@@H](CCC5)C(=O)N[C@@H]([C@H](CC)C)C(=O)N6[C@@H](CCC6)C(=O)N[C@@H](CC(=O)N)C(=O)O InChI=1S/C50H68N10O12/c1-3-29(2)42(49(70)60-24-10-16-39(60)45(66)55-35(50(71)72)27-40(52)62)56-46(67)37-14-7-21-57(37)41(63)28-53-43(64)36-13-8-23-59(36)48(69)34(26-30-11-5-4-6-12-30)54-44(65)38-15-9-22-58(38)47(68)33(51)25-31-17-19-32(61)20-18-31/h4-6,11-12,17-20,29,33-39,42,61H,3,7-10,13-16,21-28,51H2,1-2H3,(H2,52,62)(H,53,64)(H,54,65)(H,55,66)(H,56,67)(H,71,72)/t29-,33-,34-,35-,36-,37-,38-,39-,42-/m0/s1 InChIKey=WTUQPUDBBBAMBB-UDZSMLTASA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BIOPEP-UWM database of bioactive peptides ID 10116), the EROP-Moscow database, the MBPDB database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 503)
Additional Detail Fields 1 fields
9