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Peptide record

TPDB02225

Beta-casomorphin 8 - ACE inhibitor ACE inhibitors Antihypertensive Antioxidant iDPPIV standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB02225
Beta-casomorphin 8 - ACE inhibitor
ACE inhibitors Antihypertensive Antioxidant iDPPIV
Cardiometabolic peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AODB AoXpDb Multi-AOP iDPPIV
standard
No
A 8-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Antioxidant, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
YPFPGPIP
Physicochemical Analysis
C46H62N8O10
ARNDCEQHLKMSTWV
P
887.05
5.94
0
0
3
-0
-0.57
-0.100
48.75
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
167.97
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
0
L
0
K
0
M
1
F
4
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 0 M: 0 F: 1 P: 4 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
8
C46H62N8O10
887.05
5.94
-0
-0.57
-0.100
887.0296
886.4574
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
500.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Meisel H., Schlimme E.
Inhibitors of angiotensin-converting enzyme derived from casein (casokinins)/beta-Casomorphins and related peptides: recent developments. Eds. Brantl V., Teschemacher H, VCH, Weinheim, 27-33, 1994
1994
book

Other

8
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(=O)NCC(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C46H62N8O10/c1-3-28(2)39(45(62)54-24-10-16-37(54)46(63)64)50-42(59)35-14-7-21-51(35)38(56)27-48-40(57)34-13-8-23-53(34)44(61)33(26-29-11-5-4-6-12-29)49-41(58)36-15-9-22-52(36)43(60)32(47)25-30-17-19-31(55)20-18-30/h4-6,11-12,17-20,28,32-37,39,55H,3,7-10,13-16,21-27,47H2,1-2H3,(H,48,57)(H,49,58)(H,50,59)(H,63,64)/t28-,32-,33-,34-,35-,36-,37-,39-/m0/s1 InChIKey=NZONCMVKVLZPBL-AOAWOLJGSA-N Opioid peptide according to the BIOPEP-UWM database of bioactive peptides (ID 2869) Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10062) the MBPDB database
Evidence 2 Activity

Activity

IC50
Antihypertensive
500.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Meisel H., Schlimme E.
Inhibitors of angiotensin-converting enzyme derived from casein (casokinins)/beta-Casomorphins and related peptides: recent developments. Eds. Brantl V., Teschemacher H, VCH, Weinheim, 27-33, 1994
1994
book

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
8
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(=O)NCC(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C46H62N8O10/c1-3-28(2)39(45(62)54-24-10-16-37(54)46(63)64)50-42(59)35-14-7-21-51(35)38(56)27-48-40(57)34-13-8-23-53(34)44(61)33(26-29-11-5-4-6-12-29)49-41(58)36-15-9-22-52(36)43(60)32(47)25-30-17-19-31(55)20-18-30/h4-6,11-12,17-20,28,32-37,39,55H,3,7-10,13-16,21-27,47H2,1-2H3,(H,48,57)(H,49,58)(H,50,59)(H,63,64)/t28-,32-,33-,34-,35-,36-,37-,39-/m0/s1 InChIKey=NZONCMVKVLZPBL-AOAWOLJGSA-N Opioid peptide according to the BIOPEP-UWM database of bioactive peptides (ID 2869) Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10062) the MBPDB database
Additional Detail Fields 1 fields
8