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Peptide record

TPDB02202

beta-lactorphin (102-105) ACE inhibitor ACE inhibitors Antihypertensive Antioxidant standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB02202
beta-lactorphin (102-105) ACE inhibitor
ACE inhibitors Antihypertensive Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AODB
standard
No
A 4-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Antioxidant) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
YLLF
Physicochemical Analysis
C30H42N4O6
ARNDCEQGHIKMPSTWV
L
554.69
5.94
0
0
4
-0
-3.19
2.275
195.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
268.62
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
4
C30H42N4O6
554.69
5.94
-0
-3.19
2.275
554.6760
554.3094
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
172.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Mullally M. M., Meisel H., FitzGerald R. J.
Synthetic peptides corresponding to alpha-lactalbumin and beta-lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity. Biol. Chem. Hoppe-Seyler, 377, 259-261, 1996
1996
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)O InChI=1S/C30H42N4O6/c1-18(2)14-24(32-27(36)23(31)16-21-10-12-22(35)13-11-21)28(37)33-25(15-19(3)4)29(38)34-26(30(39)40)17-20-8-6-5-7-9-20/h5-13,18-19,23-26,35H,14-17,31H2,1-4H3,(H,32,36)(H,33,37)(H,34,38)(H,39,40)/t23-,24-,25-,26-/m0/s1 InChIKey=QKWJBYNAISXCRK-CQJMVLFOSA-N Opioid agonist according to the BIOPEP-UWM database of bioactive peptides (ID 3256) the MBPDB database Osteoanabolic peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10409) Immunomodulating peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10855)
Evidence 2 Activity

Activity

IC50
Antihypertensive
172.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Mullally M. M., Meisel H., FitzGerald R. J.
Synthetic peptides corresponding to alpha-lactalbumin and beta-lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity. Biol. Chem. Hoppe-Seyler, 377, 259-261, 1996
1996
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)O InChI=1S/C30H42N4O6/c1-18(2)14-24(32-27(36)23(31)16-21-10-12-22(35)13-11-21)28(37)33-25(15-19(3)4)29(38)34-26(30(39)40)17-20-8-6-5-7-9-20/h5-13,18-19,23-26,35H,14-17,31H2,1-4H3,(H,32,36)(H,33,37)(H,34,38)(H,39,40)/t23-,24-,25-,26-/m0/s1 InChIKey=QKWJBYNAISXCRK-CQJMVLFOSA-N Opioid agonist according to the BIOPEP-UWM database of bioactive peptides (ID 3256) the MBPDB database Osteoanabolic peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10409) Immunomodulating peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10855)
Additional Detail Fields 1 fields
4