TPDB

3D PDB MODEL

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TPDB ID TPDB02198

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antioxidant

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

Peptipedia AODB AoXpDb Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural multi-activity (ACE inhibitors and Antioxidant) peptide sequence curated from Peptipedia, AODB, AoXpDb, and other sources, with an available 3D structural model.

Sequence

YLGYLE

FASTA

>TPDB02198|ACE inhibitors;Antioxidant|length=6
YLGYLE

Formula C37H52N6O11

Absent Amino Acids ARNDCQHIKMFPSTWV

Common Amino Acids LY

Mass 756.85

PI 3.29

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 4

Net Charge -1

Boman Index -0.97

Hydrophobicity 0.183

Aliphatic Index 130.00

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 2980

Absorbance 280nm 393.74

Polar Residues 2

number

0

A

0

R

0

N

0

D

0

C

1

E

0

Q

1

G

0

H

0

I

2

L

0

K

0

M

0

F

0

P

0

S

0

T

0

W

2

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 2 V: 0

Length

6

Formula

C37H52N6O11

Mass

756.85

PI

3.29

Net Charge

-1

Boman Index

-0.97

Hydrophobicity

0.183

Chemical_Mass

756.8403

Monoisotopic_Mass

756.3681

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 85.76 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Amigo L., Martínez-Maqueda D., Hernández-Ledesma B.

Title In silico and in vitro analysis of multifunctionality of animal food-derived peptides. Foods, 9, 991, 2020

Year 2020

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCC(O)=O)C(O)=O InChI=1S/C37H52N6O11/c1-20(2)15-28(42-33(49)26(38)17-22-5-9-24(44)10-6-22)34(50)39-19-31(46)40-30(18-23-7-11-25(45)12-8-23)36(52)43-29(16-21(3)4)35(51)41-27(37(53)54)13-14-32(47)48/h5-12,20-21,26-30,44-45H,13-19,38H2,1-4H3,(H,39,50)(H,40,46)(H,41,51)(H,42,49)(H,43,52)(H,47,48)(H,53,54)/t26-,27-,28-,29-,30-/m0/s1 InChIKey=LEDKTLOMOHNIFX-IIZANFQQSA-N Opioid peptide according to the BIOPEP-UWM database of bioactive peptides (ID 3265) the MBPDB database Peptide stimulating mucin secretion in intestinal cells according to the BIOPEP-UWM database of bioactive peptides (ID 8338), the MBPDB database Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10057) the MBPDB database

Number_of_Residues

6