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Peptide record

TPDB02191

ACE inhibitor (from bovine beta-Lg) dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) oligopeptide ACE inhibitors Antibacterial Antifungal Antihypertensive Antioxidant Antiviral Bitter Neuropeptide iDPPIV Selfassembly standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB02191
ACE inhibitor (from bovine beta-Lg) dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) oligopeptide
ACE inhibitors Antibacterial Antifungal Antihypertensive Antioxidant Antiviral Bitter Neuropeptide iDPPIV Selfassembly
Anti-infective peptides Cardiometabolic peptides Neuroactive peptides Food sensory peptides Functional / health-promoting peptides Self-assembling and biomaterial peptides
Peptipedia CAFPdb dbAMP AHTPDB AHTpin dbAMP 3.0 Tastepeptides-Meta iDPPIV SAPdb
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
YL
Physicochemical Analysis
C15H22N2O4
ARNDCEQGHIKMFPSTWV
LY
294.35
5.94
0
0
2
-0
-1.50
1.250
195.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
506.20
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
2
C15H22N2O4
294.35
5.94
-0
-1.50
1.250
294.3453
294.1574
Self-Assembly Information 1 records
Record 1 Selfassembly

Source

30892363
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
supramolecular complexes
pH: 7 temperature: Room temperature solvent: sodium pHospHate buffer concentration: 10mM
Selfassembly; Nanostructure=supramolecular complexes; Trigger=pH: 7; temperature: Room temperature; solvent: sodium pHospHate buffer; concentration: 10mM
Selfassembly
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
122.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Mullally M. M., Meisel H., FitzGerald R. J.
Synthetic peptides corresponding to alpha-lactalbumin and beta-lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity. Biol. Chem. Hoppe-Seyler 377, 259-260, 1996
1996
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)O InChI=1S/C15H22N2O4/c1-9(2)7-13(15(20)21)17-14(19)12(16)8-10-3-5-11(18)6-4-10/h3-6,9,12-13,18H,7-8,16H2,1-2H3,(H,17,19)(H,20,21)/t12-,13-/m0/s1 InChIKey=AUEJLPRZGVVDNU-STQMWFEESA-N Peptide known as alpha/beta-lactokinin [alphas1-CN (91-92), beta-Lg (102-103)] Peptide found also in amaranth protein hydrolysate. Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Inhibitor of Dipeptidyl peptidase IV (DPP IV) (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID: 8940) Neuropeptide according to the BIOPEP-UWM database of bioactive peptides (ID: 8310) Inhibitor of Dipeptidyl peptidase III (DPP-III) (EC 3.4.14.4) (MEROPS ID: M49.003) according to the BIOPEP-UWM database of bioactive peptides (ID:9482) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID: 484) the ChEMBL database (ID: CHEMBL847173) Information concerning Dipeptidyl peptidase-III (DPP-III) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M49.001)
Evidence 2 Activity

Activity

IC50
Antihypertensive
122.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Mullally M. M., Meisel H., FitzGerald R. J.
Synthetic peptides corresponding to alpha-lactalbumin and beta-lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity. Biol. Chem. Hoppe-Seyler 377, 259-260, 1996
1996
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)O InChI=1S/C15H22N2O4/c1-9(2)7-13(15(20)21)17-14(19)12(16)8-10-3-5-11(18)6-4-10/h3-6,9,12-13,18H,7-8,16H2,1-2H3,(H,17,19)(H,20,21)/t12-,13-/m0/s1 InChIKey=AUEJLPRZGVVDNU-STQMWFEESA-N Peptide known as alpha/beta-lactokinin [alphas1-CN (91-92), beta-Lg (102-103)] Peptide found also in amaranth protein hydrolysate. Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Inhibitor of Dipeptidyl peptidase IV (DPP IV) (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID: 8940) Neuropeptide according to the BIOPEP-UWM database of bioactive peptides (ID: 8310) Inhibitor of Dipeptidyl peptidase III (DPP-III) (EC 3.4.14.4) (MEROPS ID: M49.003) according to the BIOPEP-UWM database of bioactive peptides (ID:9482) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID: 484) the ChEMBL database (ID: CHEMBL847173) Information concerning Dipeptidyl peptidase-III (DPP-III) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M49.001)
Evidence 3 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015
2015
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)O InChI=1S/C15H22N2O4/c1-9(2)7-13(15(20)21)17-14(19)12(16)8-10-3-5-11(18)6-4-10/h3-6,9,12-13,18H,7-8,16H2,1-2H3,(H,17,19)(H,20,21)/t12-,13-/m0/s1 InChIKey=AUEJLPRZGVVDNU-STQMWFEESA-N Peptide known as alpha/beta-lactokinin [alphas1-CN (91-92), beta-Lg (102-103)] Peptide found also in amaranth protein hydrolysate. Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02.001) according to the AHTPDB database the BIOPEP-UWM database of bioactive peptides (ID:3550) the BRENDA database the EROP-Moscow database Inhibitor of Dipeptidyl peptidase III (DPP-III) (EC 3.4.14.4) (MEROPS ID: M49.003) according to the BIOPEP-UWM database of bioactive peptides (ID:9482) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID: 484) the ChEMBL database (ID: CHEMBL847173) Information concerning Dipeptidyl peptidase IV (DPP IV) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: S09.003)
Evidence 4 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=supramolecular complexes Trigger=pH: 7 temperature: Room temperature solvent: sodium pHospHate buffer concentration: 10mM
supramolecular complexes

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
pH: 7 temperature: Room temperature solvent: sodium pHospHate buffer concentration: 10mM
30892363
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Additional Detail Fields 6 fields
pH: 7 temperature: Room temperature solvent: sodium pHospHate buffer concentration: 10mM
None specified
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
2
30892363
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly