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Peptide record

TPDB02185

ACE inhibitor from kappa-CN (fr. 25-30) ACE inhibitors Antihypertensive Antioxidant standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB02185
ACE inhibitor from kappa-CN (fr. 25-30)
ACE inhibitors Antihypertensive Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
pep-lab Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB AoXpDb Multi-AOP
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Antioxidant) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
YIPIQY
Physicochemical Analysis
C40H57N7O10
ARNDCEGHLKMFSTWV
IY
795.93
5.88
0
0
4
-0
-1.47
0.217
130.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
2980
374.40
3
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
2
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 2 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
6
C40H57N7O10
795.93
5.88
-0
-1.47
0.217
795.9192
795.4153
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
10.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Gomez-Ruiz J. A., Ramos M., Recio I.
Identification of novel angiotensin-converting enzyme-inhibitory peptides from ovine milk proteins by CE-MS and chromatographic techniques. Electrophoresis, 28, 4202-4211.
2007
Journal

Other

6
Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Peptide found in yoghurt: Farvin K. H. S., Baron C. P., Nielsen N. S., Jacobsen C., 2010, Antioxidant activity of yoghurt peptides: part 2 – Characterisation of peptide fractions. Food Chem., 123, 1090-1097 Reveals also antioxidative activity (BIOPEP ID 8488).
Evidence 2 Activity

Activity

IC50
Antihypertensive
10.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Gomez-Ruiz J. A., Ramos M., Recio I.
Identification of novel angiotensin-converting enzyme-inhibitory peptides from ovine milk proteins by CE-MS and chromatographic techniques. Electrophoresis, 28, 4202-4211.
2007
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Peptide found in yoghurt: Farvin K. H. S., Baron C. P., Nielsen N. S., Jacobsen C., 2010, Antioxidant activity of yoghurt peptides: part 2 – Characterisation of peptide fractions. Food Chem., 123, 1090-1097 Reveals also antioxidative activity (BIOPEP ID 8488).
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB AoXpDb
DFBP
Additional Detail Fields 1 fields
6