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Peptide record

TPDB02184

ACE inhibitor from egg yolk dipeptidyl peptidase IV inhibitor from egg yolk (DPP IV inhibitor) ACE inhibitors Antioxidant iDPPIV standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB02184
ACE inhibitor from egg yolk dipeptidyl peptidase IV inhibitor from egg yolk (DPP IV inhibitor)
ACE inhibitors Antioxidant iDPPIV
Cardiometabolic peptides Functional / health-promoting peptides
Peptipedia AODB Multi-AOP iDPPIV
standard
No
A 12-aa standard natural multi-activity (ACE inhibitors, Antioxidant, and iDPPIV) peptide sequence curated from Peptipedia, AODB, Multi-AOP, and other sources, with an available 3D structural model.
Sequence
YINQMPQKSREA
Physicochemical Analysis
C62H101N19O20S1
DCGHLFTWV
Q
1464.66
9.74
2
1
4
+1
4.33
-1.492
40.83
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
101.73
5
Residue Composition
number
1
A
1
R
1
N
0
D
0
C
1
E
2
Q
0
G
0
H
1
I
0
L
1
K
1
M
0
F
1
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 0 C: 0 E: 1 Q: 2 G: 0 H: 0 I: 1 L: 0 K: 1 M: 1 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C62H101N19O20S1
1464.66
9.74
+1
4.33
-1.492
1464.6427
1463.7168
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
12.60 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Zambrowicz A., Pokora M., Setner B., Dąbrowska A., Szołtysik M., Babij K., Szewczuk Z., Trziszka T., Lubec G., Chrzanowska J.
Multifunctional peptides derived from an egg yolk protein hydrolysate: isolation and characterization. Amino Acids 47, 369-380, 2015
2015
Journal

Other

12
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCSC)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(C)C(O)=O InChI=1S/C62H101N19O20S/c1-5-31(2)49(80-50(89)35(64)28-33-13-15-34(83)16-14-33)59(98)78-42(29-47(67)86)56(95)75-38(17-20-45(65)84)55(94)77-41(23-27-102-4)60(99)81-26-9-12-44(81)58(97)76-39(18-21-46(66)85)54(93)72-36(10-6-7-24-63)53(92)79-43(30-82)57(96)73-37(11-8-25-70-62(68)69)52(91)74-40(19-22-48(87)88)51(90)71-32(3)61(100)101/h13-16,31-32,35-44,49,82-83H,5-12,17-30,63-64H2,1-4H3,(H2,65,84)(H2,66,85)(H2,67,86)(H,71,90)(H,72,93)(H,73,96)(H,74,91)(H,75,95)(H,76,97)(H,77,94)(H,78,98)(H,79,92)(H,80,89)(H,87,88)(H,100,101)(H4,68,69,70)/t31-,32-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,49-/m0/s1 InChIKey: ZKZQTINMABVXFI-CACLQLEZSA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptide (ID 8740) Inhibitor of alpha-glucosidase (EC 3.2.1.20) according to the BIOPEP-UWM database of bioactive peptide (ID 8750)
Evidence 2 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB
DFBP
Evidence 3 Activity

Activity

IC50
iDPPIV
355.80 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Zambrowicz A., Pokora M., Setner B., Dąbrowska A., Szołtysik M., Babij K., Szewczuk Z., Trziszka T., Lubec G., Chrzanowska J.
Multifunctional peptides derived from an egg yolk protein hydrolysate: isolation and characterization. Amino Acids 47, 369-380, 2015
2015
Journal

Other

12
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCSC)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(C)C(O)=O InChI=1S/C62H101N19O20S/c1-5-31(2)49(80-50(89)35(64)28-33-13-15-34(83)16-14-33)59(98)78-42(29-47(67)86)56(95)75-38(17-20-45(65)84)55(94)77-41(23-27-102-4)60(99)81-26-9-12-44(81)58(97)76-39(18-21-46(66)85)54(93)72-36(10-6-7-24-63)53(92)79-43(30-82)57(96)73-37(11-8-25-70-62(68)69)52(91)74-40(19-22-48(87)88)51(90)71-32(3)61(100)101/h13-16,31-32,35-44,49,82-83H,5-12,17-30,63-64H2,1-4H3,(H2,65,84)(H2,66,85)(H2,67,86)(H,71,90)(H,72,93)(H,73,96)(H,74,91)(H,75,95)(H,76,97)(H,77,94)(H,78,98)(H,79,92)(H,80,89)(H,87,88)(H,100,101)(H4,68,69,70)/t31-,32-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,49-/m0/s1 InChIKey: ZKZQTINMABVXFI-CACLQLEZSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptide (ID 8744) Inhibitor of alpha-glucosidase (EC 3.2.1.20) according to the BIOPEP-UWM database of bioactive peptide (ID 8750)
Additional Detail Fields 1 fields
12