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Peptide record

TPDB02183

ACE inhibitor from egg yolk dipeptidyl peptidase IV inhibitor from egg yolk (DPP IV inhibitor) ACE inhibitors Antioxidant iDPPIV standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB02183
ACE inhibitor from egg yolk dipeptidyl peptidase IV inhibitor from egg yolk (DPP IV inhibitor)
ACE inhibitors Antioxidant iDPPIV
Cardiometabolic peptides Functional / health-promoting peptides
Peptipedia AODB Multi-AOP iDPPIV
standard
No
A 11-aa standard natural multi-activity (ACE inhibitors, Antioxidant, and iDPPIV) peptide sequence curated from Peptipedia, AODB, Multi-AOP, and other sources, with an available 3D structural model.
Sequence
YINQMPQKSRE
Physicochemical Analysis
C59H96N18O19S1
ADCGHLFTWV
Q
1393.58
9.74
2
1
3
+1
4.50
-1.791
35.45
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
106.92
5
Residue Composition
number
0
A
1
R
1
N
0
D
0
C
1
E
2
Q
0
G
0
H
1
I
0
L
1
K
1
M
0
F
1
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 0 E: 1 Q: 2 G: 0 H: 0 I: 1 L: 0 K: 1 M: 1 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
11
C59H96N18O19S1
1393.58
9.74
+1
4.50
-1.791
1393.5650
1392.6798
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
10.10 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Zambrowicz A., Pokora M., Setner B., Dąbrowska A., Szołtysik M., Babij K., Szewczuk Z., Trziszka T., Lubec G., Chrzanowska J.
Multifunctional peptides derived from an egg yolk protein hydrolysate: isolation and characterization. Amino Acids 47, 369-380, 2015
2015
Journal

Other

11
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCSC)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CCC(O)=O)C(O)=O InChI=1S/C59H96N18O19S/c1-4-30(2)47(76-48(85)33(61)27-31-12-14-32(79)15-13-31)56(93)74-40(28-45(64)82)53(90)70-36(16-19-43(62)80)52(89)72-38(22-26-97-3)57(94)77-25-8-11-42(77)55(92)71-37(17-20-44(63)81)51(88)68-34(9-5-6-23-60)50(87)75-41(29-78)54(91)69-35(10-7-24-67-59(65)66)49(86)73-39(58(95)96)18-21-46(83)84/h12-15,30,33-42,47,78-79H,4-11,16-29,60-61H2,1-3H3,(H2,62,80)(H2,63,81)(H2,64,82)(H,68,88)(H,69,91)(H,70,90)(H,71,92)(H,72,89)(H,73,86)(H,74,93)(H,75,87)(H,76,85)(H,83,84)(H,95,96)(H4,65,66,67)/t30-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,47-/m0/s1 InChIKey: WOGLIZJTFLKEIL-FQOONHDLSA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8739) Inhibitor of alpha-glucosidase (EC 3.2.1.20) according to the BIOPEP-UWM database of bioactive peptides (ID 8747)
Evidence 2 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB
DFBP
Evidence 3 Activity

Activity

IC50
iDPPIV
222.80 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Zambrowicz A., Pokora M., Setner B., Dąbrowska A., Szołtysik M., Babij K., Szewczuk Z., Trziszka T., Lubec G., Chrzanowska J.
Multifunctional peptides derived from an egg yolk protein hydrolysate: isolation and characterization. Amino Acids 47, 369-380, 2015
2015
Journal

Other

11
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCSC)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CCC(O)=O)C(O)=O InChI=1S/C59H96N18O19S/c1-4-30(2)47(76-48(85)33(61)27-31-12-14-32(79)15-13-31)56(93)74-40(28-45(64)82)53(90)70-36(16-19-43(62)80)52(89)72-38(22-26-97-3)57(94)77-25-8-11-42(77)55(92)71-37(17-20-44(63)81)51(88)68-34(9-5-6-23-60)50(87)75-41(29-78)54(91)69-35(10-7-24-67-59(65)66)49(86)73-39(58(95)96)18-21-46(83)84/h12-15,30,33-42,47,78-79H,4-11,16-29,60-61H2,1-3H3,(H2,62,80)(H2,63,81)(H2,64,82)(H,68,88)(H,69,91)(H,70,90)(H,71,92)(H,72,89)(H,73,86)(H,74,93)(H,75,87)(H,76,85)(H,83,84)(H,95,96)(H4,65,66,67)/t30-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,47-/m0/s1 InChIKey: WOGLIZJTFLKEIL-FQOONHDLSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 8742) Inhibitor of alpha-glucosidase (EC 3.2.1.20) according to the BIOPEP-UWM database of bioactive peptides (ID 8747)
Additional Detail Fields 1 fields
11