TPDB

3D PDB MODEL

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TPDB ID TPDB02172

Peptide_Name

alpha-lactorphin - ACE inhibitor

Activity

ACE inhibitors Antihypertensive Antioxidant Bitter

Activity_category_statistics

Cardiometabolic peptides Food sensory peptides Functional / health-promoting peptides

Database_Source

Peptipedia AHTPDB AHTpin AODB Multi-AOP Tastepeptides-Meta

Sequence_Type

standard

Has_Modification No

Description A 4-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Antioxidant, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.

Sequence

YGLF

FASTA

>TPDB02172|ACE inhibitors;Antihypertensive;Antioxidant;Bitter|length=4
YGLF

Formula C26H34N4O6

Absent Amino Acids ARNDCEQHIKMPSTWV

Common Amino Acids GLFY

Mass 498.58

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 3

Net Charge -0

Boman Index -2.62

Hydrophobicity 1.225

Aliphatic Index 97.50

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 298.85

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

1

L

0

K

0

M

1

F

0

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

4

Formula

C26H34N4O6

Mass

498.58

PI

5.94

Net Charge

-0

Boman Index

-2.62

Hydrophobicity

1.225

Chemical_Mass

498.5700

Monoisotopic_Mass

498.2470

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 733.30 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Mullally M. M., Meisel H., FitzGerald R. J.

Title

Synthetic peptides corresponding to alpha-lactalbumin and beta-lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity. Biol. Chem. Hoppe-Seyler, 377, 259-260, 1996

Year 1996

Literature Source Journal

Other

Number of Residues 4

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [C@H](N)(CC1=CC=C(C=C1)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC2=CC=CC=C2)C(O)=O InChI=1S/C26H34N4O6/c1-16(2)12-21(25(34)30-22(26(35)36)14-17-6-4-3-5-7-17)29-23(32)15-28-24(33)20(27)13-18-8-10-19(31)11-9-18/h3-11,16,20-22,31H,12-15,27H2,1-2H3,(H,28,33)(H,29,32)(H,30,34)(H,35,36)/t20-,21-,22-/m0/s1 InChIKey= JMEQPUQYEDILLR-FKBYEOEOSA-N Opioid agonist according to the BIOPEP-UWM database of bioactive peptides (ID 3552) Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10101) the MBPDB database Mucin secretion simulating peptide according to the BIOPEP-UWM database of bioactive peptides (10114) the MBPDB database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 501), the EROP-Moscow database

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 733.30 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Mullally M. M., Meisel H., FitzGerald R. J.

Title

Synthetic peptides corresponding to alpha-lactalbumin and beta-lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity. Biol. Chem. Hoppe-Seyler, 377, 259-260, 1996

Year 1996

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 4

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [C@H](N)(CC1=CC=C(C=C1)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC2=CC=CC=C2)C(O)=O InChI=1S/C26H34N4O6/c1-16(2)12-21(25(34)30-22(26(35)36)14-17-6-4-3-5-7-17)29-23(32)15-28-24(33)20(27)13-18-8-10-19(31)11-9-18/h3-11,16,20-22,31H,12-15,27H2,1-2H3,(H,28,33)(H,29,32)(H,30,34)(H,35,36)/t20-,21-,22-/m0/s1 InChIKey= JMEQPUQYEDILLR-FKBYEOEOSA-N Opioid agonist according to the BIOPEP-UWM database of bioactive peptides (ID 3552) Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10101) the MBPDB database Mucin secretion simulating peptide according to the BIOPEP-UWM database of bioactive peptides (10114) the MBPDB database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 501), the EROP-Moscow database

Number_of_Residues

4