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Peptide record

TPDB02171

ACE inhibitor (from bovine a-La) ACE inhibitors Antihypertensive Antioxidant standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB02171
ACE inhibitor (from bovine a-La)
ACE inhibitors Antihypertensive Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AODB Multi-AOP
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Antioxidant) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
YGL
Physicochemical Analysis
C17H25N3O5
ARNDCEQHIKMFPSTWV
GLY
351.40
5.94
0
0
2
-0
-1.49
0.700
130.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
424.02
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
3
C17H25N3O5
351.40
5.94
-0
-1.49
0.700
351.3965
351.1788
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
409.00 µM
ACE inhibitor
ah

Source & Reference

NA
Pihlanto-Leppala A. et al.
Angiotensin I-converting enzyme inhibitory properties of whey protein digests: concentration and characterization of active peptides.J. Dairy Res., 67, 53-64
2000
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(O)=O InChI=1S/C17H25N3O5/c1-10(2)7-14(17(24)25)20-15(22)9-19-16(23)13(18)8-11-3-5-12(21)6-4-11/h3-6,10,13-14,21H,7-9,18H2,1-2H3,(H,19,23)(H,20,22)(H,24,25)/t13-,14-/m0/s1 InChIKey=KCPFDGNYAMKZQP-KBPBESRZSA-N EC50(IC50)= 1552uM. from: Meisel H., Walsh D. J., Murray B., FitzGerald R. J.(2006). ACE inhibitory peptides. in: Nutraceutical proteins and peptides in health and disease. Mine Y., Shahidi F. (Eds.), CRC Taylor & Francis Group, Boca Raton, London, New York, 269-315.
Evidence 2 Activity

Activity

IC50
Antihypertensive
409.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
Pihlanto-Leppala A. et al.
Angiotensin I-converting enzyme inhibitory properties of whey protein digests: concentration and characterization of active peptides.J. Dairy Res., 67, 53-64
2000
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(O)=O InChI=1S/C17H25N3O5/c1-10(2)7-14(17(24)25)20-15(22)9-19-16(23)13(18)8-11-3-5-12(21)6-4-11/h3-6,10,13-14,21H,7-9,18H2,1-2H3,(H,19,23)(H,20,22)(H,24,25)/t13-,14-/m0/s1 InChIKey=KCPFDGNYAMKZQP-KBPBESRZSA-N EC50(IC50)= 1552uM. from: Meisel H., Walsh D. J., Murray B., FitzGerald R. J.(2006). ACE inhibitory peptides. in: Nutraceutical proteins and peptides in health and disease. Mine Y., Shahidi F. (Eds.), CRC Taylor & Francis Group, Boca Raton, London, New York, 269-315.
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB
DFBP
Additional Detail Fields 1 fields
3