Peptide record

TPDB02166

[Met5] Enkephalin Met-enkephalin Met-Enkephalins Proenkephalin-A Anticancer Antidiabetic Antioxidant Blood-Brain Barrier Neuropeptide standard

5 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB02166

Peptide_Name

[Met5] Enkephalin Met-enkephalin Met-Enkephalins Proenkephalin-A

Activity

Anticancer Antidiabetic Antioxidant Blood-Brain Barrier Neuropeptide

Activity_category_statistics

Cardiometabolic peptides Cancer-related peptides Delivery and barrier-penetrating peptides Neuroactive peptides Functional / health-promoting peptides

Database_Source

Peptipedia pep-lab AnOxPePred - 1.0 AODB AoXpDb Multi-AOP B3Pred BBPpredict

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (Anticancer, Antidiabetic, Antioxidant, and other sources) peptide sequence curated from Peptipedia, pep-lab, AnOxPePred - 1.0, and other sources, with an available 3D structural model.

Sequence

YGGFM

FASTA

>TPDB02166|Anticancer;Antidiabetic;Antioxidant;Blood-Brain Barrier;Neuropeptide|length=5
YGGFM

Formula C27H35N5O7S1

Absent Amino Acids ARNDCEQHILKPSTWV

Common Amino Acids G

Mass 573.66

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 3

Net Charge -0

Boman Index -2.28

Hydrophobicity 0.520

Aliphatic Index 0.00

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 259.73

Polar Residues 1

number

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 1 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

Formula

C27H35N5O7S1

Mass

573.66

5.94

Net Charge

-0

Boman Index

-2.28

Hydrophobicity

0.520

Conformation

Pentapeptide Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Tyr-Gly-Gly-Phe-Met Tyr-Gly-Gly-Phe-Met-OH

SMILES

N[C@@]([H])(Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCSC)C(=O)O O=C(O)C(NC(=O)C(NC(=O)CNC(=O)CNC(=O)C(N)Cc1ccc(O)cc1)Cc2ccccc2)CCSC

Evidence 1 Activity

Activity

Main Bioactivity Antioxidative activity

Detail Source Activity Antioxidant

Source & Reference

Database Source AODB AoXpDb

Source DFBP

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Assay & Model

Animal Model Origin/Source

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Intestine and Brain

BBB Action morphine-like actions and addictive properties

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Assay & Model

Animal Model Origin/Source

In Vivo Concentration 20 micromole/Kg

In Vivo Method Hot water tail flick test

In Vivo Result Analgesic effect seen within 2 seconds

Physical Condition Alzheimer

Source & Reference

Database Source NA

Source B3Pdb

Other

In Vivo Mode of Delivery Intraperitoneal

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Assay & Model

In Vitro Method Adult Wistar SPF rats

Animal Model Origin/Source

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Intestine and Brain

BBB Action morphine-like actions and addictive properties

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 48

Assay & Model

Animal Model Origin/Source

Response Blood/brain ratio

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin mouse,rat

In Vivo Mode of Delivery Intracarotid injection

Transport Type Permeability

Label Direct iodination

Evidence 6 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00002 cm/s

Assay & Model

In Vitro Method BMEC

Animal Model Origin/Source

Response Permeability coefficient

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin mouse,rat

Transport Type Permeability

Evidence 7 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.0000774 cm/s

Assay & Model

In Vitro Method BMEC

Animal Model Origin/Source

Response Permeability coefficient

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin mouse,rat

Transport Type Permeability

Evidence 8 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Acipenser transmontanus

Family Opioid

Evidence 9 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Bos taurus

Family Opioid

Evidence 10 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Camelus dromedarius

Family Opioid

Evidence 11 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Cavia porcellus

Family Opioid

Evidence 12 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Opioid growth factor receptor Delta-type opioid receptor

Receptor Organisms Homo sapiens Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family Opioid

Receptor Lengths 677 372

Receptor Ligands NP08114 NP08092 NP08081 NP08163 NP08168 NP08174 NP08239 NP07973 NP08005 NP08011 NP08027 NP08034 NP08040 NP08114 NP08068 NP08075 NP08123 NP08130 NP08247 NP08092

Evidence 13 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Lepisosteus osseus

Family Opioid

Evidence 14 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Lithobates catesbeianus

Family Opioid

Evidence 15 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Loxodonta africana

Family Opioid

Evidence 16 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Macaca nemestrina

Family Opioid

Evidence 17 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Opioid growth factor receptor Delta-type opioid receptor

Receptor Organisms Mus musculus Mus musculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family Opioid

Receptor Lengths 633 372

Receptor Ligands NP08116 NP08097 NP08069 NP08116 NP08136 NP08132 NP08249 NP08077 NP08097

Evidence 18 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Neovison vison

Family Opioid

Evidence 19 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Oncorhynchus keta

Family Opioid

Evidence 20 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Pelophylax ridibundus

Family Opioid

Evidence 21 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Delta-type opioid receptor

Receptor Organisms Sus scrofa

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Sus scrofa

Family Opioid

Receptor Lengths 228

Receptor Ligands NP08070 NP08101

Evidence 22 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Melanocortin receptor 3 Melanocortin receptor 4 Melanocortin receptor 5 Delta-type opioid receptor

Receptor Organisms Rattus norvegicus Rattus norvegicus Rattus norvegicus Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family Opioid

Receptor Lengths 323 332 325 372

Receptor Ligands NP08992 NP09095 NP09119 NP09142 NP08102 NP08992 NP09095 NP09119 NP09142 NP08102 NP08992 NP09095 NP09119 NP09142 NP08102 NP07976 NP08008 NP08014 NP08030 NP08037 NP08043 NP08071 NP08084 NP08242 NP08117 NP08125 NP08133 NP08166 NP08172 NP08178 NP08250 NP08078 NP07992 NP08102

Evidence 23 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Ovis aries

Family Opioid

Evidence 24 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Thunnus obesus

Family Opioid

Evidence 25 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Cyprinus carpio

Family Opioid

Evidence 26 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Oncorhynchus mykiss

Family Opioid

Evidence 27 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Xenopus laevis

Family Opioid

Evidence 28 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Theromyzon tessulatum

Family Opioid

Evidence 29 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Felis catus

Family Opioid

Evidence 30 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mesocricetus auratus

Family Opioid

Evidence 31 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Opioid growth factor receptor Delta-type opioid receptor

Receptor Organisms Rattus norvegicus Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family Opioid

Receptor Lengths 580 372

Receptor Ligands NP08117 NP07976 NP08008 NP08014 NP08030 NP08037 NP08043 NP08071 NP08084 NP08242 NP08117 NP08125 NP08133 NP08166 NP08172 NP08178 NP08250 NP08078 NP07992 NP08102

Evidence 32 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Meiacanthus atrodorsalis

Family Opioid

Evidence 33 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Hippocampus

Family Opioid

Evidence 34 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family Opioid

Family

Opioid

In_Vivo_Mode_of_Delivery

Intraperitoneal Intracarotid injection

Receptor_Lengths

677 372 633 228 323 332 325 580

Receptor_Ligands

NP08114 NP08092 NP08081 NP08163 NP08168 NP08174 NP08239 NP07973 NP08005 NP08011 NP08027 NP08034 NP08040 NP08068 NP08075 NP08123 NP08130 NP08247 NP08116 NP08097 NP08069 NP08136 NP08132 NP08249 NP08077 NP08070 NP08101 NP08992 NP09095 NP09119 NP09142 NP08102 NP07976 NP08008 NP08014 NP08030 NP08037 NP08043 NP08071 NP08084 NP08242 NP08117 NP08125 NP08133 NP08166 NP08172 NP08178 NP08250 NP08078 NP07992