Peptide record

TPDB02165

[Leu5] Enkephalin Leu-enkephalin Leu-Enkephalins Proenkephalin-A Antidiabetic Antioxidant Blood-Brain Barrier Neuropeptide standard

5 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB02165

Peptide_Name

[Leu5] Enkephalin Leu-enkephalin Leu-Enkephalins Proenkephalin-A

Activity

Antidiabetic Antioxidant Blood-Brain Barrier Neuropeptide

Activity_category_statistics

Cardiometabolic peptides Delivery and barrier-penetrating peptides Neuroactive peptides Functional / health-promoting peptides

Database_Source

Peptipedia AnOxPePred - 1.0 AODB AoXpDb Multi-AOP B3Pred BBPpredict

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (Antidiabetic, Antioxidant, Blood-Brain Barrier, and other sources) peptide sequence curated from Peptipedia, AnOxPePred - 1.0, AODB, and other sources, with an available 3D structural model.

Sequence

YGGFL

FASTA

>TPDB02165|Antidiabetic;Antioxidant;Blood-Brain Barrier;Neuropeptide|length=5
YGGFL

Formula C28H37N5O7

Absent Amino Acids ARNDCEQHIKMPSTWV

Common Amino Acids G

Mass 555.63

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 3

Net Charge -0

Boman Index -2.61

Hydrophobicity 0.900

Aliphatic Index 78.00

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 268.16

Polar Residues 1

number

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

Formula

C28H37N5O7

Mass

555.63

5.94

Net Charge

-0

Boman Index

-2.61

Hydrophobicity

0.900

Conformation

Pentapeptide Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Tyr-Gly-Gly-Phe-Leu Tyr-Gly-Gly-Phe-Leu-OH

SMILES

N[C@@]([H])(Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)O O=C(O)C(NC(=O)C(NC(=O)CNC(=O)CNC(=O)C(N)Cc1ccc(O)cc1)Cc2ccccc2)CC(C)C

Evidence 1 Activity

Activity

Main Bioactivity Antioxidative activity

Detail Source Activity Antioxidant

Source & Reference

Database Source AODB AoXpDb

Source DFBP

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Assay & Model

Animal Model Origin/Source

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Intestine and Brain

BBB Action morphine-like actions and addictive properties

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Assay & Model

Animal Model Origin/Source

In Vivo Concentration 20 micromole/Kg

In Vivo Method Hot water tail flick test

In Vivo Result Analgesic effect seen within 2 seconds

Physical Condition Alzheimer

Source & Reference

Database Source NA

Source B3Pdb

Other

In Vivo Mode of Delivery Intraperitoneal

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Assay & Model

In Vitro Method Adult Wistar SPF rats

Animal Model Origin/Source

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Intestine and Brain

BBB Action morphine-like actions and addictive properties

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 69

Assay & Model

Animal Model Origin/Source

Response Blood/brain ratio

Source & Reference

Database Source NA

Source B3Pdb

Other

In Vivo Mode of Delivery Intracarotid injection

Transport Type Permeability

Label Direct iodination

Evidence 6 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Aplysia californica

Family Opioid

Evidence 7 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Bos taurus

Family Opioid

Evidence 8 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Cavia porcellus

Family Opioid

Evidence 9 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Delta-type opioid receptor

Receptor Organisms Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family Opioid

Receptor Lengths 372

Receptor Ligands NP08081 NP08163 NP08168 NP08174 NP08239 NP07973 NP08005 NP08011 NP08027 NP08034 NP08040 NP08114 NP08068 NP08075 NP08123 NP08130 NP08247 NP08092

Evidence 10 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Delta-type opioid receptor

Receptor Organisms Mus musculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family Opioid

Receptor Lengths 372

Receptor Ligands NP08069 NP08116 NP08136 NP08132 NP08249 NP08077 NP08097

Evidence 11 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Delta-type opioid receptor

Receptor Organisms Sus scrofa

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Sus scrofa

Family Opioid

Receptor Lengths 228

Receptor Ligands NP08070 NP08101

Evidence 12 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Delta-type opioid receptor

Receptor Organisms Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family Opioid

Receptor Lengths 372

Receptor Ligands NP07976 NP08008 NP08014 NP08030 NP08037 NP08043 NP08071 NP08084 NP08242 NP08117 NP08125 NP08133 NP08166 NP08172 NP08178 NP08250 NP08078 NP07992 NP08102

Evidence 13 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Felis catus

Family Opioid

Evidence 14 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mesocricetus auratus

Family Opioid

Evidence 15 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Hippocampus

Family Opioid

Evidence 16 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family Opioid

Family

Opioid

In_Vivo_Mode_of_Delivery

Intraperitoneal Intracarotid injection

Receptor_Lengths

372 228

Receptor_Ligands

NP08081 NP08163 NP08168 NP08174 NP08239 NP07973 NP08005 NP08011 NP08027 NP08034 NP08040 NP08114 NP08068 NP08075 NP08123 NP08130 NP08247 NP08092 NP08069 NP08116 NP08136 NP08132 NP08249 NP08077 NP08097 NP08070 NP08101 NP07976 NP08008 NP08014 NP08030 NP08037 NP08043 NP08071 NP08084 NP08242 NP08117 NP08125 NP08133 NP08166 NP08172 NP08178 NP08250 NP08078 NP07992 NP08102