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Peptide record

TPDB02163

ACE inhibitor ACE inhibitors Antihypertensive Antioxidant Neuropeptide standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB02163
ACE inhibitor
ACE inhibitors Antihypertensive Antioxidant Neuropeptide
Cardiometabolic peptides Neuroactive peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AODB AoXpDb Multi-AOP
standard
No
A 5-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Antioxidant, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
YGFLP
Physicochemical Analysis
C31H41N5O7
ARNDCEQHIKMSTWV
GLFPY
595.70
5.94
0
0
3
-0
-2.17
0.660
78.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
250.13
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
1
L
0
K
0
M
1
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
5
C31H41N5O7
595.70
5.94
-0
-2.17
0.660
595.6849
595.2996
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
260.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C31H41N5O7/c1-19(2)15-25(30(41)36-14-6-9-26(36)31(42)43)35-29(40)24(17-20-7-4-3-5-8-20)34-27(38)18-33-28(39)23(32)16-21-10-12-22(37)13-11-21/h3-5,7-8,10-13,19,23-26,37H,6,9,14-18,32H2,1-2H3,(H,33,39)(H,34,38)(H,35,40)(H,42,43)/t23-,24-,25-,26-/m0/s1 InChIKey: ZQTCRHZZZRSODS-CQJMVLFOSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Opioid peptide according to the BIOPEP-UWM database of bioactive peptides (ID 2866) the EROP-Moscow database Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10090), the MBPDB database
Evidence 2 Activity

Activity

IC50
Antihypertensive
260.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Kohmura M., Nio N., Kubo K., Minoshima Y., Munekata E., Ariyoshi Y.
Inhibition of angiotensin-converting enzyme by synthetic peptides of human beta-casein. Agric. Biol. Chem., 53(8), 2107-2114 (1989)
1989
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
5
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C31H41N5O7/c1-19(2)15-25(30(41)36-14-6-9-26(36)31(42)43)35-29(40)24(17-20-7-4-3-5-8-20)34-27(38)18-33-28(39)23(32)16-21-10-12-22(37)13-11-21/h3-5,7-8,10-13,19,23-26,37H,6,9,14-18,32H2,1-2H3,(H,33,39)(H,34,38)(H,35,40)(H,42,43)/t23-,24-,25-,26-/m0/s1 InChIKey: ZQTCRHZZZRSODS-CQJMVLFOSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Opioid peptide according to the BIOPEP-UWM database of bioactive peptides (ID 2866) the EROP-Moscow database Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10090), the MBPDB database
Additional Detail Fields 1 fields
5