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Peptide record

TPDB02155

ACE inhibitor from as1-CN (144-149) Antioxidative peptide ACE inhibitors Antihypertensive Antioxidant standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB02155
ACE inhibitor from as1-CN (144-149) Antioxidative peptide
ACE inhibitors Antihypertensive Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB AoXpDb Multi-AOP
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Antioxidant) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
YFYPEL
Physicochemical Analysis
C43H54N6O11
ARNDCQGHIKMSTWV
Y
830.94
3.29
0
1
4
-1
-1.10
-0.183
65.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
2980
358.63
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
1
F
1
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
6
C43H54N6O11
830.94
3.29
-1
-1.10
-0.183
830.9203
831 Da
3.34
830.3837
0.00
N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(C)C)C(=O)O
830.92 Da
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
ACE inhibitor
ah

Source & Reference

NA
De Gobba C., Tompa G., Otte J.
Bioactive peptides from caseins released by cold active proteolytic enzymes from Arsukibacterium ikkense. Food Chemistry 165, 205-215.
2014
Journal

Other

6
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
ACE inhibitor
ah

Source & Reference

AHTPDB
De Gobba C., Tompa G., Otte J.
Bioactive peptides from caseins released by cold active proteolytic enzymes from Arsukibacterium ikkense. Food Chemistry 165, 205-215.
2014
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
Evidence 3 Activity

Activity

Antioxidative activity
ACE-inhibitory activity
scavenging activity
The peptide showed potent superoxide anion scavenging activity with the IC 50 vaule of 79.2 μM. The activities of the peptide to scavenge hydroxyl radical produced in the system of H 2 O 2 -Fe 2+ and DPPH radical were 251 μM and 98μM, respectively.
Literature report: N.D Prediction: ToxinPred
Antioxidant
79.2 µM

Assay & Model

DPPH hydroxyl radical scavenging superoxide radical scavenging
Enzymatic hydrolysis
Peptide obtained by hydrolysis of milk casein by use of pepsin.

Source & Reference

AODB AoXpDb
Suetsuna K, Ukeda H, Ochi H. Isolation and characterization of free radical scavenging activities peptides derived from casein. J Nutr Biochem. 2000 Mar 11(3):128-31.
10.1016/s0955-2863(99)00083-2
[1] Pihlanto A. Antioxidative peptides derived from milk proteins[J]. International Dairy Journal, 2006, 16(11):1306-1314. [2] Ranathunga S, Rajapakse S, Kim S K. Purification and characterization of antioxidative peptide derived from muscle of conger eel (Conger myriaster)[J]. European Food Research & Technology, 2006, 222(3-4):310-315.
2000
DFBP

Other

Native peptide
Animal
Milk protien
α
f(144-149)
Additional Detail Fields 2 fields
6
f(144-149)