TPDB

3D PDB MODEL

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TPDB ID TPDB02145

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antioxidant

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

Peptipedia AODB AoXpDb

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural multi-activity (ACE inhibitors and Antioxidant) peptide sequence curated from Peptipedia, AODB, and AoXpDb, with an available 3D structural model.

Sequence

YETGNGIK

FASTA

>TPDB02145|ACE inhibitors;Antioxidant|length=8
YETGNGIK

Formula C38H60N10O14

Absent Amino Acids ARDCQHLMFPSWV

Common Amino Acids G

Mass 880.95

PI 6.87

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 2

Net Charge -0

Boman Index 2.34

Hydrophobicity -1.150

Aliphatic Index 48.75

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 169.14

Polar Residues 3

number

0

A

0

R

1

N

0

D

0

C

1

E

0

Q

2

G

0

H

1

I

0

L

1

K

0

M

0

F

0

P

0

S

1

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 1 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 1 V: 0

Length

8

Formula

C38H60N10O14

Mass

880.95

PI

6.87

Net Charge

-0

Boman Index

2.34

Hydrophobicity

-1.150

Chemical_Mass

880.9392

Monoisotopic_Mass

880.4276

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 3.69 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Zielińska E., Karaś M., Baraniak B., Jakubczyk A.

Title

Evaluation of ACE, alpha‑glucosidase, and lipase inhibitory activities of peptides obtained by in vitro digestion of selected species of edible insects. Eur. Food Res. Technol., 246, 1361-1369, 2020

Year 2020

Literature Source Journal

Other

Number of Residues 8

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@H](O)C)C(=O)NCC(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](CCCCN)C(=O)O InChI=1S/C38H60N10O14/c1-4-19(2)31(37(60)46-25(38(61)62)7-5-6-14-39)47-29(53)18-42-34(57)26(16-27(41)51)44-28(52)17-43-36(59)32(20(3)49)48-35(58)24(12-13-30(54)55)45-33(56)23(40)15-21-8-10-22(50)11-9-21/h8-11,19-20,23-26,31-32,49-50H,4-7,12-18,39-40H2,1-3H3,(H2,41,51)(H,42,57)(H,43,59)(H,44,52)(H,45,56)(H,46,60)(H,47,53)(H,48,58)(H,54,55)(H,61,62)/t19-,20+,23-,24-,25-,26-,31-,32-/m0/s1 InChIKey=ZBGYYJXTWBVMEG-TZCYLVGHSA-N Inhibitor of pancreatic lipase according to the BIOPEP-UWM database of bioactive peptides (ID 9847)

Number_of_Residues

8