TPDB

3D PDB MODEL

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TPDB ID TPDB02136

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antioxidant

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

Peptipedia AODB AoXpDb Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural multi-activity (ACE inhibitors and Antioxidant) peptide sequence curated from Peptipedia, AODB, AoXpDb, and other sources, with an available 3D structural model.

Sequence

YDDGSYKPH

FASTA

>TPDB02136|ACE inhibitors;Antioxidant|length=9
YDDGSYKPH

Formula C48H64N12O17

Absent Amino Acids ARNCEQILMFTWV

Common Amino Acids DY

Mass 1081.11

PI 5.10

Basic Residues 2

Acidic Residues 2

Hydrophobic Residues 2

Net Charge -1

Boman Index 3.12

Hydrophobicity -2.167

Aliphatic Index 0.00

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 2980

Absorbance 280nm 275.64

Polar Residues 3

number

0

A

0

R

0

N

2

D

0

C

0

E

0

Q

1

G

1

H

0

I

0

L

1

K

0

M

0

F

1

P

1

S

0

T

0

W

2

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 2 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 0 K: 1 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 2 V: 0

Length

9

Formula

C48H64N12O17

Mass

1081.11

PI

5.10

Net Charge

-1

Boman Index

3.12

Hydrophobicity

-2.167

Chemical_Mass

1081.0894

Monoisotopic_Mass

1080.4497

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 5.38 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Zielińska E., Karaś M., Baraniak B., Jakubczyk A.

Title

Evaluation of ACE, alpha‑glucosidase, and lipase inhibitory activities of peptides obtained by in vitro digestion of selected species of edible insects. Eur. Food Res. Technol., 246, 1361-1369, 2020

Year 2020

Literature Source Journal

Other

Number of Residues 9

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CCCCN)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](CC4=C[N]([H])C=N4)C(=O)O InChI=1S/C48H64N12O17/c49-14-2-1-4-31(47(75)60-15-3-5-37(60)46(74)59-35(48(76)77)18-27-21-51-24-53-27)55-43(71)32(17-26-8-12-29(63)13-9-26)57-45(73)36(23-61)54-38(64)22-52-42(70)33(19-39(65)66)58-44(72)34(20-40(67)68)56-41(69)30(50)16-25-6-10-28(62)11-7-25/h6-13,21,24,30-37,61-63H,1-5,14-20,22-23,49-50H2,(H,51,53)(H,52,70)(H,54,64)(H,55,71)(H,56,69)(H,57,73)(H,58,72)(H,59,74)(H,65,66)(H,67,68)(H,76,77)/t30-,31-,32-,33-,34-,35-,36-,37-/m0/s1 InChIKey=YYAFFTNFHUOXAT-MDKUUQCZSA-N Pancreatic lipase inhibitor according to the BIOPEP-UWM database of bioactive peptides (ID 9833)

Number_of_Residues

9