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Peptide record

TPDB02128

ACE inhibitor from egg white ACE inhibitors Antihypertensive Antioxidant Neuropeptide standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB02128
ACE inhibitor from egg white
ACE inhibitors Antihypertensive Antioxidant Neuropeptide
Cardiometabolic peptides Neuroactive peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB AoXpDb Multi-AOP
standard
No
A 9-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Antioxidant, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
YAEERYPIL
Physicochemical Analysis
C54H80N12O16
NDCQGHKMFSTWV
EY
1153.30
4.26
1
2
5
-1
2.38
-0.622
97.78
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
2980
258.39
2
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
2
E
0
Q
0
G
0
H
1
I
1
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 2 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
9
C54H80N12O16
1153.30
4.26
-1
2.38
-0.622
1153.2806
1152.5796
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Babij K., Dąbrowska A., Szołtysik M., Pokora M., Zambrowicz A., Chrzanowska J.
Int. J. Pept. Res. Ther., 20, 483–491, 2014
2014
Journal

Other

9
Full title of reference paper: The Evaluation of Dipeptidyl Peptidase (DPP)-IV, alpha-Glucosidase and Angiotensin Converting Enzyme (ACE) Inhibitory Activities of Whey Proteins Hydrolyzed with Serine Protease Isolated from Asian Pumpkin (Cucurbita ficifolia). Int. J. Pept. Res. Ther., 20, 483–491, 2014 (authors: Babij K., Dąbrowska A., Szołtysik M., Pokora M., Zambrowicz A., Chrzanowska J.). BIOPEP database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CC(C)C)C(O)=O InChI=1S/C54H80N12O16/c1-6-29(4)44(51(79)64-40(53(81)82)25-28(2)3)65-50(78)41-10-8-24-66(41)52(80)39(27-32-13-17-34(68)18-14-32)63-47(75)36(9-7-23-58-54(56)57)61-49(77)38(20-22-43(71)72)62-48(76)37(19-21-42(69)70)60-45(73)30(5)59-46(74)35(55)26-31-11-15-33(67)16-12-31/h11-18,28-30,35-41,44,67-68H,6-10,19-27,55H2,1-5H3,(H,59,74)(H,60,73)(H,61,77)(H,62,76)(H,63,75)(H,64,79)(H,65,78)(H,69,70)(H,71,72)(H,81,82)(H4,56,57,58)/t29-,30-,35-,36-,37-,38-,39-,40-,41-,44-/m0/s1 INChIKey: KJFSHDGRGPPBOK-KLCRLARCSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Babij K., Dąbrowska A., Szołtysik M., Pokora M., Zambrowicz A., Chrzanowska J.
Int. J. Pept. Res. Ther., 20, 483–491, 2014
2014
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
9
Full title of reference paper: The Evaluation of Dipeptidyl Peptidase (DPP)-IV, alpha-Glucosidase and Angiotensin Converting Enzyme (ACE) Inhibitory Activities of Whey Proteins Hydrolyzed with Serine Protease Isolated from Asian Pumpkin (Cucurbita ficifolia). Int. J. Pept. Res. Ther., 20, 483–491, 2014 (authors: Babij K., Dąbrowska A., Szołtysik M., Pokora M., Zambrowicz A., Chrzanowska J.). BIOPEP database of bioactive peptides SMILES: [H][C@](N)(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CC(C)C)C(O)=O InChI=1S/C54H80N12O16/c1-6-29(4)44(51(79)64-40(53(81)82)25-28(2)3)65-50(78)41-10-8-24-66(41)52(80)39(27-32-13-17-34(68)18-14-32)63-47(75)36(9-7-23-58-54(56)57)61-49(77)38(20-22-43(71)72)62-48(76)37(19-21-42(69)70)60-45(73)30(5)59-46(74)35(55)26-31-11-15-33(67)16-12-31/h11-18,28-30,35-41,44,67-68H,6-10,19-27,55H2,1-5H3,(H,59,74)(H,60,73)(H,61,77)(H,62,76)(H,63,75)(H,64,79)(H,65,78)(H,69,70)(H,71,72)(H,81,82)(H4,56,57,58)/t29-,30-,35-,36-,37-,38-,39-,40-,41-,44-/m0/s1 INChIKey: KJFSHDGRGPPBOK-KLCRLARCSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB AoXpDb
DFBP
Additional Detail Fields 1 fields
9