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Peptide record

TPDB02121

ACE inhibitor Antihypertensive Antioxidant standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB02121
ACE inhibitor
Antihypertensive Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
AHTPDB AHTpin Peptipedia AnOxPePred - 1.0 AODB AoXpDb Multi-AOP
standard
No
A 7-aa standard natural multi-activity (Antihypertensive and Antioxidant) peptide sequence curated from AHTPDB, AHTpin, Peptipedia, and other sources, with an available 3D structural model.
Sequence
WYSLAMA
Physicochemical Analysis
C40H56N8O10S1
RNDCEQGHIKFPTV
A
840.99
5.94
0
0
6
-0
-3.79
0.900
84.29
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
6990
831.16
2
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
1
M
0
F
0
P
1
S
0
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 1 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 1 V: 0
Chemical Descriptors
7
C40H56N8O10S1
840.99
5.94
-0
-3.79
0.900
840.9841
840.3827
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
Antihypertensive
0.00 µM
Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Hernandez-Ledesma B., Amigo L., Recio I., Bartolome B.
ACE-inhibitory and radical scavenging activity of peptides derived from β-lactoglobulin f(19-25). Interactions with ascorbic acid. J. Agric. Food Chem., 55 (2007), 3392-3397.
2007
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
7
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C)C(=O)O InChI=1S/C40H56N8O10S/c1-21(2)16-31(37(54)43-22(3)34(51)45-30(14-15-59-5)36(53)44-23(4)40(57)58)47-39(56)33(20-49)48-38(55)32(17-24-10-12-26(50)13-11-24)46-35(52)28(41)18-25-19-42-29-9-7-6-8-27(25)29/h6-13,19,21-23,28,30-33,42,49-50H,14-18,20,41H2,1-5H3,(H,43,54)(H,44,53)(H,45,51)(H,46,52)(H,47,56)(H,48,55)(H,57,58)/t22-,23-,28-,30-,31-,32-,33-/m0/s1 InChIKey=AAFTWQSHOBITFF-NFUJUSGDSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 7905) the DFBP database the EROP-Moscow database
Evidence 2 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB AoXpDb
DFBP
Additional Detail Fields 1 fields
7