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Peptide record

TPDB02120

ACE inhibitor Antihypertensive Antioxidant standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB02120
ACE inhibitor
Antihypertensive Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
AHTPDB AHTpin Peptipedia AnOxPePred - 1.0 AODB AoXpDb Multi-AOP
standard
No
A 6-aa standard natural multi-activity (Antihypertensive and Antioxidant) peptide sequence curated from AHTPDB, AHTpin, Peptipedia, and other sources, with an available 3D structural model.
Sequence
WYSLAM
Physicochemical Analysis
C37H51N7O9S1
RNDCEQGHIKFPTV
ALMSWY
769.91
5.94
0
0
5
-0
-3.62
0.750
81.67
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
6990
907.89
2
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
1
M
0
F
0
P
1
S
0
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 1 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 1 V: 0
Chemical Descriptors
6
C37H51N7O9S1
769.91
5.94
-0
-3.62
0.750
769.9064
769.3457
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
Antihypertensive
59.90 µM
Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Hernandez-Ledesma B., Amigo L., Recio I., Bartolome B.
ACE-inhibitory and radical scavenging activity of peptides derived from β-lactoglobulin f(19-25). Interactions with ascorbic acid. J. Agric. Food Chem., 55 (2007), 3392-3397.
2007
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCSC)C(=O)O InChI=1S/C37H51N7O9S/c1-20(2)15-29(34(49)40-21(3)32(47)41-28(37(52)53)13-14-54-4)43-36(51)31(19-45)44-35(50)30(16-22-9-11-24(46)12-10-22)42-33(48)26(38)17-23-18-39-27-8-6-5-7-25(23)27/h5-12,18,20-21,26,28-31,39,45-46H,13-17,19,38H2,1-4H3,(H,40,49)(H,41,47)(H,42,48)(H,43,51)(H,44,50)(H,52,53)/t21-,26-,28-,29-,30-,31-/m0/s1 InChIKey=SDXGIPZTSQUZRR-WPPHWVMVSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 7905) the DFBP database the EROP-Moscow database
Evidence 2 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB AoXpDb
DFBP
Additional Detail Fields 1 fields
6