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Peptide record

TPDB02119

ACE inhibitor Antihypertensive Antioxidant standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB02119
ACE inhibitor
Antihypertensive Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
AHTPDB AHTpin Peptipedia AnOxPePred - 1.0 AODB AoXpDb Multi-AOP
standard
No
A 5-aa standard natural multi-activity (Antihypertensive and Antioxidant) peptide sequence curated from AHTPDB, AHTpin, Peptipedia, and other sources, with an available 3D structural model.
Sequence
WYSLA
Physicochemical Analysis
C32H42N6O8
RNDCEQGHIKMFPTV
ALSWY
638.72
5.94
0
0
4
-0
-3.39
0.520
98.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
6990
1094.37
2
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
1
S
0
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 1 V: 0
Chemical Descriptors
5
C32H42N6O8
638.72
5.94
-0
-3.39
0.520
638.7096
638.3054
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
Antihypertensive
86.90 µM
Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Hernandez-Ledesma B., Amigo L., Recio I., Bartolome B.
ACE-inhibitory and radical scavenging activity of peptides derived from β-lactoglobulin f(19-25). Interactions with ascorbic acid. J. Agric. Food Chem., 55 (2007), 3392-3397.
2007
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
5
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)O InChI=1S/C32H42N6O8/c1-17(2)12-25(29(42)35-18(3)32(45)46)37-31(44)27(16-39)38-30(43)26(13-19-8-10-21(40)11-9-19)36-28(41)23(33)14-20-15-34-24-7-5-4-6-22(20)24/h4-11,15,17-18,23,25-27,34,39-40H,12-14,16,33H2,1-3H3,(H,35,42)(H,36,41)(H,37,44)(H,38,43)(H,45,46)/t18-,23-,25-,26-,27-/m0/s1 InChIKey=BULJOIIMFHXRBC-ICMIYAPYSA-N Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 79020) the DFBP database the EROP-Moscow database
Evidence 2 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB AoXpDb
DFBP
Additional Detail Fields 1 fields
5