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Peptide record

TPDB02118

ACE inhibitor Antihypertensive Antioxidant standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB02118
ACE inhibitor
Antihypertensive Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
AHTPDB AHTpin Peptipedia AnOxPePred - 1.0 AODB Multi-AOP
standard
No
A 4-aa standard natural multi-activity (Antihypertensive and Antioxidant) peptide sequence curated from AHTPDB, AHTpin, Peptipedia, and other sources, with an available 3D structural model.
Sequence
WYSL
Physicochemical Analysis
C29H37N5O7
ARNDCEQGHIKMFPTV
LSWY
567.64
5.94
0
0
3
-0
-3.22
0.200
97.50
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
6990
1231.41
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
1
S
0
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 1 V: 0
Chemical Descriptors
4
C29H37N5O7
567.64
5.94
-0
-3.22
0.200
567.6319
567.2684
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
Antihypertensive
90.40 µM
Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Hernandez-Ledesma B., Amigo L., Recio I., Bartolome B.
ACE-inhibitory and radical scavenging activity of peptides derived from β-lactoglobulin f(19-25). Interactions with ascorbic acid. J. Agric. Food Chem., 55 (2007), 3392-3397.
2027
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(C)C)C(=O)O InChI=1S/C29H37N5O7/c1-16(2)11-24(29(40)41)33-28(39)25(15-35)34-27(38)23(12-17-7-9-19(36)10-8-17)32-26(37)21(30)13-18-14-31-22-6-4-3-5-20(18)22/h3-10,14,16,21,23-25,31,35-36H,11-13,15,30H2,1-2H3,(H,32,37)(H,33,39)(H,34,38)(H,40,41)/t21-,23-,24-,25-/m0/s1 InChIKey=BEGTZUPTEIHUQM-LFBFJMOVSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 7901) the DFBP database
Evidence 2 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB
DFBP
Additional Detail Fields 1 fields
4