Back to search

Peptide record

TPDB02107

ACE inhibitor renin inhibitor ACE inhibitors Antihypertensive Antioxidant standard
4 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB02107
ACE inhibitor renin inhibitor
ACE inhibitors Antihypertensive Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
Peptipedia AnOxPePred - 1.0 AODB Multi-AOP
standard
No
A 4-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Antioxidant) peptide sequence curated from Peptipedia, AnOxPePred - 1.0, AODB, and other sources, with an available 3D structural model.
Sequence
WVYY
Physicochemical Analysis
C34H39N5O7
ARNDCEQGHILKMFPST
Y
629.71
5.88
0
0
4
-0
-3.66
0.175
72.50
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
8480
1346.65
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 2 V: 1
Chemical Descriptors
4
C34H39N5O7
629.71
5.88
-0
-3.66
0.175
629.7012
629.2840
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
27.00 µM
Inhibitor of angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Girgih AT, He R, Aluko RE.
Kinetics and molecular docking studies of the inhibitions of angiotensin converting enzyme and renin activities by hemp seed (Cannabis sativa L.) peptides. J. Agric. Food Chem. 62, 4135−4144, 2014
2014
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[N]([H])C2=CC=CC=C12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)N[C@@H](CC4=CC=C(C=C4)O)C(=O)O InChI= 1S/C34H39N5O7/c1-19(2)30(39-31(42)26(35)17-22-18-36-27-6-4-3-5-25(22)27)33(44)37-28(15-20-7-11-23(40)12-8-20)32(43)38-29(34(45)46)16-21-9-13-24(41)14-10-21/h3-14,18-19,26,28-30,36,40-41H,15-17,35H2,1-2H3,(H,37,44)(H,38,43)(H,39,42)(H,45,46)/t26-,28-,29-,30-/m0/s1 InChIKey: PRZWESBMSHMINZ-SYKYGTKKSA-N Antioxidative peptide according to the EROP-Moscow databases
Evidence 2 Activity

Activity

IC50
Antihypertensive
27.00 µM
Inhibitor of angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Girgih AT, He R, Aluko RE.
Kinetics and molecular docking studies of the inhibitions of angiotensin converting enzyme and renin activities by hemp seed (Cannabis sativa L.) peptides. J. Agric. Food Chem. 62, 4135−4144, 2014
2014
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[N]([H])C2=CC=CC=C12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)N[C@@H](CC4=CC=C(C=C4)O)C(=O)O InChI= 1S/C34H39N5O7/c1-19(2)30(39-31(42)26(35)17-22-18-36-27-6-4-3-5-25(22)27)33(44)37-28(15-20-7-11-23(40)12-8-20)32(43)38-29(34(45)46)16-21-9-13-24(41)14-10-21/h3-14,18-19,26,28-30,36,40-41H,15-17,35H2,1-2H3,(H,37,44)(H,38,43)(H,39,42)(H,45,46)/t26-,28-,29-,30-/m0/s1 InChIKey: PRZWESBMSHMINZ-SYKYGTKKSA-N Antioxidative peptide according to the EROP-Moscow databases
Evidence 3 Activity

Activity

EC50
Antihypertensive
0.00 µM
Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007)
renin inhibitor
ren

Source & Reference

NA
Girgih AT, He R, Malomo SA, Offengenden M, Wu J, Aluko RE.
Structural and functional characterization of hemp seed (Cannabis sativa L.) protein-derived antioxidant and antihypertensive peptides. J. Funct. Foods 6, 384–394.
2014
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[N]([H])C2=CC=CC=C12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)N[C@@H](CC4=CC=C(C=C4)O)C(=O)O InChI= 1S/C34H39N5O7/c1-19(2)30(39-31(42)26(35)17-22-18-36-27-6-4-3-5-25(22)27)33(44)37-28(15-20-7-11-23(40)12-8-20)32(43)38-29(34(45)46)16-21-9-13-24(41)14-10-21/h3-14,18-19,26,28-30,36,40-41H,15-17,35H2,1-2H3,(H,37,44)(H,38,43)(H,39,42)(H,45,46)/t26-,28-,29-,30-/m0/s1 InChIKey: PRZWESBMSHMINZ-SYKYGTKKSA-N
Evidence 4 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB
DFBP
Additional Detail Fields 1 fields
4