TPDB

3D PDB MODEL

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TPDB ID TPDB02105

Peptide_Name

Anti-inflammatory peptide

Activity

Anti-inflammatory Antioxidant

Activity_category_statistics

Immunity and inflammation peptides Functional / health-promoting peptides

Database_Source

Peptipedia AODB AoXpDb Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural multi-activity (Anti-inflammatory and Antioxidant) peptide sequence curated from Peptipedia, AODB, AoXpDb, and other sources, with an available 3D structural model.

Sequence

WVSPLAGRT

FASTA

>TPDB02105|Anti-inflammatory;Antioxidant|length=9
WVSPLAGRT

Formula C45H71N13O12

Absent Amino Acids NDCEQHIKMFY

Common Amino Acids ARGLPSTWV

Mass 986.14

PI 11.05

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +1

Boman Index -0.97

Hydrophobicity 0.100

Aliphatic Index 86.67

Half Life

Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 557.73

Polar Residues 2

number

1

A

1

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

1

L

0

K

0

M

0

F

1

P

1

S

1

T

1

W

0

Y

1

V

Amino Acid Distribution

A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 1 T: 1 W: 1 Y: 0 V: 1

Length

9

Formula

C45H71N13O12

Mass

986.14

PI

11.05

Net Charge

+1

Boman Index

-0.97

Hydrophobicity

0.100

Chemical_Mass

986.1223

Monoisotopic_Mass

985.5329

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Anti-inflammatory

Activity Measurement 0.00 µM

Function Anti-inflammatory

Detail Activity anti inflammatory

Activity Code ai

Source & Reference

Database Source NA

Authors Cruz-Chamorro I., Santos-Sánchez G., Bollati C., Bartolomei M., Li J., Arnoldi A., Lammi C.

Title

Hempseed (Cannabis sativa) peptides WVSPLAGRT and IGFLIIWV exert anti-inflammatory activity in the LPS-stimulated human hepatic cell line. J. Agric. Food Chem., 70, 577–583, 2022

Year 2022

Literature Source Journal

Other

Number of Residues 9

Additional Info

BIOPEP-UWM database of bioactive peptids SMILES: N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)O InChI=1S/C45H71N13O12/c1-22(2)17-31(40(65)52-24(5)37(62)51-20-34(61)53-30(13-9-15-49-45(47)48)39(64)57-36(25(6)60)44(69)70)54-41(66)33-14-10-16-58(33)43(68)32(21-59)55-42(67)35(23(3)4)56-38(63)28(46)18-26-19-50-29-12-8-7-11-27(26)29/h7-8,11-12,19,22-25,28,30-33,35-36,50,59-60H,9-10,13-18,20-21,46H2,1-6H3,(H,51,62)(H,52,65)(H,53,61)(H,54,66)(H,55,67)(H,56,63)(H,57,64)(H,69,70)(H4,47,48,49)/t24-,25+,28-,30-,31-,32-,33-,35-,36-/m0/s1 InChIKey=NKYTWSAISGYNAB-XPMGFRCRSA-N

Number_of_Residues

9