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Peptide record

TPDB02102

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Antihypertensive Antioxidant iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB02102
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
Antihypertensive Antioxidant iDPPIV
Cardiometabolic peptides Functional / health-promoting peptides
AHTPDB AHTpin Peptipedia AODB iDPPIV
standard
No
A 2-aa standard natural multi-activity (Antihypertensive, Antioxidant, and iDPPIV) peptide sequence curated from AHTPDB, AHTpin, Peptipedia, and other sources, with an available 3D structural model.
Sequence
WV
Physicochemical Analysis
C16H21N3O3
ARNDCEQGHILKMFPSTY
WV
303.36
6.02
0
0
2
-0
-1.78
1.650
145.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
1813.02
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
2
C16H21N3O3
303.36
6.02
-0
-1.78
1.650
303.3554
303.1578
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
Antihypertensive
500.50 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Ono S., Hosokawa M., Miyashita K., Takahashi K.
Inhibition properties of dipeptides from salmon muscle hydrolysate on angiotensin I-converting enzyme. Int. J. Food Sci. Technol., 41, 363-366, 2006
2006
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@]([H])(C(C)C)C(=O)O InChI=1S/C16H21N3O3/c1-9(2)14(16(21)22)19-15(20)12(17)7-10-8-18-13-6-4-3-5-11(10)13/h3-6,8-9,12,14,18H,7,17H2,1-2H3,(H,19,20)(H,21,22)/t12-,14-/m0/s1 InChIKey=LWFWZRANSFAJDR-JSGCOSHPSA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8556), the DFBP database the EROP-Moscow database Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database, the DFBP database the EROP-Moscow database Antioxidative peptide according to the DFBP database Inhibitor of Xanthine oxidase (EC 1.17.3.2) according to the BIOPEP-UWM database of bioactive peptides the DFBP database, the EROP-Moscow database
Evidence 2 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB
DFBP
Evidence 3 Activity

Activity

IC50
iDPPIV
65.69 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Nongonierma A. B., Mooney C., Shields D. C., FitzGerald R. J.
Inhibition of dipeptidyl peptidase IV and xanthine oxidase by amino acids and dipeptides. Food Chemistry, 141, 644-653, 2013
2013
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@]([H])(C(C)C)C(=O)O InChI=1S/C16H21N3O3/c1-9(2)14(16(21)22)19-15(20)12(17)7-10-8-18-13-6-4-3-5-11(10)13/h3-6,8-9,12,14,18H,7,17H2,1-2H3,(H,19,20)(H,21,22)/t12-,14-/m0/s1 InChIKey=LWFWZRANSFAJDR-JSGCOSHPSA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8556), the DFBP database the EROP-Moscow database Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database, the DFBP database the EROP-Moscow database Inhibitor of Xanthine oxidase (EC 1.17.3.2) according to the BIOPEP-UWM database of bioactive peptides the DFBP database, the EROP-Moscow database Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides the DFBP database
Additional Detail Fields 1 fields
2