TPDB

3D PDB MODEL

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TPDB ID TPDB02099

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antioxidant

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

Peptipedia AnOxPePred - 1.0 AODB Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 3-aa standard natural multi-activity (ACE inhibitors and Antioxidant) peptide sequence curated from Peptipedia, AnOxPePred - 1.0, AODB, and other sources, with an available 3D structural model.

Sequence

WSY

FASTA

>TPDB02099|ACE inhibitors;Antioxidant|length=3
WSY

Formula C23H26N4O6

Absent Amino Acids ARNDCEQGHILKMFPTV

Common Amino Acids SWY

Mass 454.48

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 2

Net Charge -0

Boman Index -2.66

Hydrophobicity -1.000

Aliphatic Index 0.00

Half Life

Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 6990

Absorbance 280nm 1538.01

Polar Residues 2

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

0

F

0

P

1

S

0

T

1

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 1 V: 0

Length

3

Formula

C23H26N4O6

Mass

454.48

PI

5.94

Net Charge

-0

Boman Index

-2.66

Hydrophobicity

-1.000

Chemical_Mass

454.4747

Monoisotopic_Mass

454.1846

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Girgih AT, He R, Malomo SA, Offengenden M, Wu J, Aluko RE.

Title

Structural and functional characterization of hemp seed (Cannabis sativa L.) protein-derived antioxidant and antihypertensive peptides. J. Funct. Foods 6, 384–394.

Year 2014

Literature Source Journal

Other

Number of Residues 3

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[N]([H])C2=CC=CC=C12)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)O InChI= 1S/C23H26N4O6/c24-17(10-14-11-25-18-4-2-1-3-16(14)18)21(30)27-20(12-28)22(31)26-19(23(32)33)9-13-5-7-15(29)8-6-13/h1-8,11,17,19-20,25,28-29H,9-10,12,24H2,(H,26,31)(H,27,30)(H,32,33)/t17-,19-,20-/m0/s1 InChIKey: ABRICLFKFRFDKS-IHPCNDPISA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10012) Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007) according to the BIOPEP-UWM database of bioactive peptides (ID 10014)

Evidence 2 Activity

Activity

Main Bioactivity Antioxidative activity

Detail Source Activity Antioxidant

Source & Reference

Database Source AODB

Source DFBP

Number_of_Residues

3