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Peptide record

TPDB02081

ACE inhibitor ACE inhibitors Antihypertensive Antioxidant standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB02081
ACE inhibitor
ACE inhibitors Antihypertensive Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin Multi-AOP
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Antioxidant) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
WLP
Physicochemical Analysis
C22H30N4O4
ARNDCEQGHIKMFSTYV
LPW
414.50
6.02
0
0
2
-0
-1.96
0.433
130.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
1326.89
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
1
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
3
C22H30N4O4
414.50
6.02
-0
-1.96
0.433
414.4968
414.2260
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Terashima M., Oe M., Ogura K., Matsumura S.
Inhibition strength of short peptides derived from an ACE inhibitory peptide. J. Agric. Food Chem., 59, 11234-11237, 2011
2011
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C22H30N4O4/c1-13(2)10-18(21(28)26-9-5-8-19(26)22(29)30)25-20(27)16(23)11-14-12-24-17-7-4-3-6-15(14)17/h3-4,6-7,12-13,16,18-19,24H,5,8-11,23H2,1-2H3,(H,25,27)(H,29,30)/t16-,18-,19-/m0/s1 InChIKey=GWBWCGITOYODER-WDSOQIARSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10229)
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Terashima M., Oe M., Ogura K., Matsumura S.
Inhibition strength of short peptides derived from an ACE inhibitory peptide. J. Agric. Food Chem., 59, 11234-11237, 2011
2011
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C22H30N4O4/c1-13(2)10-18(21(28)26-9-5-8-19(26)22(29)30)25-20(27)16(23)11-14-12-24-17-7-4-3-6-15(14)17/h3-4,6-7,12-13,16,18-19,24H,5,8-11,23H2,1-2H3,(H,25,27)(H,29,30)/t16-,18-,19-/m0/s1 InChIKey=GWBWCGITOYODER-WDSOQIARSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10229)
Additional Detail Fields 1 fields
3