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Peptide record

TPDB02077

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antibacterial Anticancer Antifungal Antihypertensive Antioxidant Toxicity iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB02077
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antibacterial Anticancer Antifungal Antihypertensive Antioxidant Toxicity iDPPIV
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides Functional / health-promoting peptides
FermFooDB Peptipedia CancerPPD 2.0 CAFPdb dbAMP AHTPDB AHTpin AODB Multi-AOP iDPPIV
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Anticancer, and other sources) peptide sequence curated from FermFooDB, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
WL
Physicochemical Analysis
C17H23N3O3
ARNDCEQGHIKMFPSTYV
LW
317.39
6.02
0
0
2
-0
-2.41
1.450
195.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
1732.90
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
2
C17H23N3O3
317.39
6.02
-0
-2.41
1.450
317.3819
317.1734
Evidence Records 7 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
41.40 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Khedr S., Martin M., Deussen A.
Inhibitory efficacy and biological variability of tryptophan containing dipeptides on human plasma angiotensin converting enzyme activity. J. Hypertens., 4, Article No 1000198, 2015
2015
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: CC(C)C[C@H](NC(=O)[C@@H](N)CC1=CNC2=CC=CC=C12)C(O)=O InChI=1S/C17H23N3O3/c1-10(2)7-15(17(22)23)20-16(21)13(18)8-11-9-19-14-6-4-3-5-12(11)14/h3-6,9-10,13,15,19H,7-8,18H2,1-2H3,(H,20,21)(H,22,23)/t13-,15-/m0/s1 InChIKey: LYMVXFSTACVOLP-ZFWWWQNUSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Activity measured using rabbit lung ACE. Activities measured against human plasma ACE and human recombinant ACE, are 81.6 and 85.3 micromoles respectively. Khedr S., Martin M., Deussen A., 2015, Inhibitory efficacy and biological variability of tryptophan containing dipeptides on human plasma angiotensin converting enzyme activity. J. Hypertens., 4, Article No 1000198 Inhibitor of Peroxisome proliferator-activated receptor gamma according to BindingDB database ChEMBL database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8677) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids the BitterDB database
Evidence 2 Activity

Activity

IC50
Antihypertensive
41.40 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Khedr S., Martin M., Deussen A.
Inhibitory efficacy and biological variability of tryptophan containing dipeptides on human plasma angiotensin converting enzyme activity. J. Hypertens., 4, Article No 1000198, 2015
2015
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: CC(C)C[C@H](NC(=O)[C@@H](N)CC1=CNC2=CC=CC=C12)C(O)=O InChI=1S/C17H23N3O3/c1-10(2)7-15(17(22)23)20-16(21)13(18)8-11-9-19-14-6-4-3-5-12(11)14/h3-6,9-10,13,15,19H,7-8,18H2,1-2H3,(H,20,21)(H,22,23)/t13-,15-/m0/s1 InChIKey: LYMVXFSTACVOLP-ZFWWWQNUSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Activity measured using rabbit lung ACE. Activities measured against human plasma ACE and human recombinant ACE, are 81.6 and 85.3 micromoles respectively. Khedr S., Martin M., Deussen A., 2015, Inhibitory efficacy and biological variability of tryptophan containing dipeptides on human plasma angiotensin converting enzyme activity. J. Hypertens., 4, Article No 1000198 Inhibitor of Peroxisome proliferator-activated receptor gamma according to BindingDB database ChEMBL database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8677) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids the BitterDB database
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB FermFooDB
DFBP
Evidence 4 Activity

Activity

50% Cell death
Toxicity
>100 µM
Cytotoxic
50% Cell death | >100 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Purification, structural elucidation and bioactivity of tryptophan containing diketopiperazines, from Comamonas testosteroni associated with a rhabditid entomopathogenic nematode against major human-pathogenic bacteria. | Peptides | 2014
Evidence 5 Activity

Activity

50% Cell death
Toxicity
100 µM
Cytotoxic
50% Cell death | 100 | µM | target cell: Human fibroblasts

Target

Human fibroblasts

Source & Reference

NA
DBAASP
Purification, structural elucidation and bioactivity of tryptophan containing diketopiperazines, from Comamonas testosteroni associated with a rhabditid entomopathogenic nematode against major human-pathogenic bacteria. | Peptides | 2014
Evidence 6 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Molecules. 2020 Aug 12 25(16):3676.
Evidence 7 Activity

Activity

IC50
iDPPIV
43.60 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Nongonierma A. B., Mooney C., Shields D. C., FitzGerald R. J.
In silico approaches to predict the potential of milk protein-derived peptides as dipeptidyl peptidase IV (DPP-IV) inhibitors. Peptides 57, 43-51, 2014
2014
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: CC(C)C[C@H](NC(=O)[C@@H](N)CC1=CNC2=CC=CC=C12)C(O)=O InChI=1S/C17H23N3O3/c1-10(2)7-15(17(22)23)20-16(21)13(18)8-11-9-19-14-6-4-3-5-12(11)14/h3-6,9-10,13,15,19H,7-8,18H2,1-2H3,(H,20,21)(H,22,23)/t13-,15-/m0/s1 InChIKey: LYMVXFSTACVOLP-ZFWWWQNUSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of Peroxisome proliferator-activated receptor gamma according to BindingDB database ChEMBL database Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 9107) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids the BitterDB database
Additional Detail Fields 1 fields
2