Back to search

Peptide record

TPDB02072

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antioxidant iDPPIV standard
4 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB02072
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antioxidant iDPPIV
Cardiometabolic peptides Functional / health-promoting peptides
Peptipedia AODB Multi-AOP iDPPIV
standard
No
A 4-aa standard natural multi-activity (ACE inhibitors, Antioxidant, and iDPPIV) peptide sequence curated from Peptipedia, AODB, Multi-AOP, and other sources, with an available 3D structural model.
Sequence
WIQP
Physicochemical Analysis
C27H38N6O6
ARNDCEGHLKMFSTYV
QIPW
542.64
6.02
0
0
2
-0
-1.13
-0.375
97.50
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
1013.57
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
4
C27H38N6O6
542.64
6.02
-0
-1.13
-0.375
542.6257
542.2844
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
14.20 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5 MEROPS ID: S09.003)
ACE inhibitor
ah

Source & Reference

NA
Norris R., O’Keeffe M. B., Poyarkov A., FitzGerald R. J.
Peptide identification and angiotensin converting enzyme (ACE) inhibitory activity in prolyl endoproteinase digests of bovine alpha-s-casein. Food Chem., 188, 210-217, 2015
2015
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[N]([H])C2=CC=CC=C12)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N3[C@@H](CCC3)C(=O)O InChI=1S/C27H38N6O6/c1-3-15(2)23(32-24(35)18(28)13-16-14-30-19-8-5-4-7-17(16)19)25(36)31-20(10-11-22(29)34)26(37)33-12-6-9-21(33)27(38)39/h4-5,7-8,14-15,18,20-21,23,30H,3,6,9-13,28H2,1-2H3,(H2,29,34)(H,31,36)(H,32,35)(H,38,39)/t15-,18-,20-,21-,23-/m0/s1 InChIKey=REZGYTATDGOWRW-AZJJULKRSA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8592) the MBPDB database
Evidence 2 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB
DFBP
Evidence 3 Activity

Activity

IC50
iDPPIV
237.30 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Nongonierma A. B., FitzGerald R. J.
Inhibition of dipeptidyl peptidase IV (DPP-IV) by proline containing casein-derived peptides. J. Funct. Foods, 5, 1909-1917, 2013
2013
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[N]([H])C2=CC=CC=C12)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N3[C@@H](CCC3)C(=O)O InChI=1S/C27H38N6O6/c1-3-15(2)23(32-24(35)18(28)13-16-14-30-19-8-5-4-7-17(16)19)25(36)31-20(10-11-22(29)34)26(37)33-12-6-9-21(33)27(38)39/h4-5,7-8,14-15,18,20-21,23,30H,3,6,9-13,28H2,1-2H3,(H2,29,34)(H,31,36)(H,32,35)(H,38,39)/t15-,18-,20-,21-,23-/m0/s1 InChIKey=REZGYTATDGOWRW-AZJJULKRSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 10098) the EROP-Moscow database the MBPDB database
Additional Detail Fields 1 fields
4