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Peptide record

TPDB02036

ACE inhibitor from sake lees dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antihypertensive Antioxidant Neuropeptide iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB02036
ACE inhibitor from sake lees dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antihypertensive Antioxidant Neuropeptide iDPPIV
Cardiometabolic peptides Neuroactive peptides Functional / health-promoting peptides
FermFooDB Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB Multi-AOP iDPPIV
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Antioxidant, and other sources) peptide sequence curated from FermFooDB, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
VW
Physicochemical Analysis
C16H21N3O3
ARNDCEQGHILKMFPSTY
WV
303.36
6.02
0
0
2
-0
-1.78
1.650
145.00
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
5500
1813.02
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
2
C16H21N3O3
303.36
6.02
-0
-1.78
1.650
303.3554
303.1578
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
1.40 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Saito Y., Wanezaki K., Kawato A., Imayasu S.
Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees. Biosci. Biotech. Biochem. 58(10), 1767-1771 (1994)
1994
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C(C)C)C(=O)N[C@@H](Cc1c2ccccc2[nH]c1)C(=O)O InChI=1S/C16H21N3O3/c1-9(2)14(17)15(20)19-13(16(21)22)7-10-8-18-12-6-4-3-5-11(10)12/h3-6,8-9,13-14,18H,7,17H2,1-2H3,(H,19,20)(H,21,22)/t13-,14-/m0/s1 InChIKey: LZDNBBYBDGBADK-KBPBESRZSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Another value of peptide IC50(EC50)=1,6 uM Cushman D. W., 1981. Angiotensin converting enzyme inhibitors:Evolution of a new class of antihypertensive drugs (page 19). in: Horovitz Z. P. (Ed.)(1981), Mechanisms of action and clinical implications, Urban & Schwarzenberg. Another value of peptide IC50(EC50)=2,4 uM Ono S., Hosokawa M., Miyashita K., Takahashi K., 2003, Isolation of peptides with angiotensin I-converting enzyme inhibitory effect derived from hydrolysate of upstream chum salmon muszle. J. Food Sci., 68, 1611-1614 Peptide found also in chum salmon muscle protein hydrolysate. Ono S., Hosokawa M., Miyashita K., Takahashi K., 2003, Isolation of peptides with angiotensin I-converting enzyme inhibitory effect derived from hydrolysate of upstream chum salmon muscle. J. Food Sci., 68, 1611-1614 Peptide found also in amaranth protein hydrolysate. Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8461) Prolactin releasing activity according to the EROP-Moscow database Inhibitor of Xanthine oxidase (EC 1.17.3.2) according to the EROP-Moscow database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8928) Inhibitor of alpha-glucosidase (EC 3.2.1.20) according to the BIOPEP-UWM database of bioactive peptides (ID 9387)
Evidence 2 Activity

Activity

IC50
Antihypertensive
1.40 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Saito Y., Wanezaki K., Kawato A., Imayasu S.
Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees. Biosci. Biotech. Biochem. 58(10), 1767-1771 (1994)
1994
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C(C)C)C(=O)N[C@@H](Cc1c2ccccc2[nH]c1)C(=O)O InChI=1S/C16H21N3O3/c1-9(2)14(17)15(20)19-13(16(21)22)7-10-8-18-12-6-4-3-5-11(10)12/h3-6,8-9,13-14,18H,7,17H2,1-2H3,(H,19,20)(H,21,22)/t13-,14-/m0/s1 InChIKey: LZDNBBYBDGBADK-KBPBESRZSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Another value of peptide IC50(EC50)=1,6 uM Cushman D. W., 1981. Angiotensin converting enzyme inhibitors:Evolution of a new class of antihypertensive drugs (page 19). in: Horovitz Z. P. (Ed.)(1981), Mechanisms of action and clinical implications, Urban & Schwarzenberg. Another value of peptide IC50(EC50)=2,4 uM Ono S., Hosokawa M., Miyashita K., Takahashi K., 2003, Isolation of peptides with angiotensin I-converting enzyme inhibitory effect derived from hydrolysate of upstream chum salmon muszle. J. Food Sci., 68, 1611-1614 Peptide found also in chum salmon muscle protein hydrolysate. Ono S., Hosokawa M., Miyashita K., Takahashi K., 2003, Isolation of peptides with angiotensin I-converting enzyme inhibitory effect derived from hydrolysate of upstream chum salmon muscle. J. Food Sci., 68, 1611-1614 Peptide found also in amaranth protein hydrolysate. Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8461) Prolactin releasing activity according to the EROP-Moscow database Inhibitor of Xanthine oxidase (EC 1.17.3.2) according to the EROP-Moscow database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8928) Inhibitor of alpha-glucosidase (EC 3.2.1.20) according to the BIOPEP-UWM database of bioactive peptides (ID 9387)
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB FermFooDB
DFBP
Evidence 4 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015
2015
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C(C)C)C(=O)N[C@@H](Cc1c2ccccc2[nH]c1)C(=O)O InChI=1S/C16H21N3O3/c1-9(2)14(17)15(20)19-13(16(21)22)7-10-8-18-12-6-4-3-5-11(10)12/h3-6,8-9,13-14,18H,7,17H2,1-2H3,(H,19,20)(H,21,22)/t13-,14-/m0/s1 InChIKey: LZDNBBYBDGBADK-KBPBESRZSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8461) Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BIOPEP-UWM database of bioactive peptides (ID 3486) the BRENDA database the ChEMBL database the EROP-Moscow database the PubChem database Prolactin releasing activity according to the EROP-Moscow database Inhibitor of Xanthine oxidase (EC 1.17.3.2) according to the EROP-Moscow database Inhibitor of alpha-glucosidase (EC 3.2.1.20) according to the BIOPEP-UWM database of bioactive peptides (ID 9387)
Additional Detail Fields 1 fields
2