TPDB

3D PDB MODEL

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TPDB ID TPDB02028

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antioxidant

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

Peptipedia AODB Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 4-aa standard natural multi-activity (ACE inhibitors and Antioxidant) peptide sequence curated from Peptipedia, AODB, and Multi-AOP, with an available 3D structural model.

Sequence

VVLY

FASTA

>TPDB02028|ACE inhibitors;Antioxidant|length=4
VVLY

Formula C25H40N4O6

Absent Amino Acids ARNDCEQGHIKMFPSTW

Common Amino Acids V

Mass 492.62

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 4

Net Charge -0

Boman Index -1.36

Hydrophobicity 2.725

Aliphatic Index 242.50

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 302.47

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

1

L

0

K

0

M

0

F

0

P

0

S

0

T

0

W

1

Y

2

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 2

Length

4

Formula

C25H40N4O6

Mass

492.62

PI

5.94

Net Charge

-0

Boman Index

-1.36

Hydrophobicity

2.725

Chemical_Mass

492.6067

Monoisotopic_Mass

492.2938

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 533.90 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Zheng Y., Li Y., Zhang Y., Ruan X., Zhang R.

Title

Purification, characterization, synthesis, in vitro ACE inhibition and in vivo antihypertensive activity of bioactive peptides derived from oil palm kernel glutelin-2 hydrolysates. J. Funct. Foods, 28, 48-58, 2017

Year 2017

Literature Source Journal

Other

Number of Residues 4

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O InChI=1S/C25H40N4O6/c1-13(2)11-18(27-24(33)21(15(5)6)29-23(32)20(26)14(3)4)22(31)28-19(25(34)35)12-16-7-9-17(30)10-8-16/h7-10,13-15,18-21,30H,11-12,26H2,1-6H3,(H,27,33)(H,28,31)(H,29,32)(H,34,35)/t18-,19-,20-,21-/m0/s1 InChIKey: CENMFAQMDPCXIV-TUFLPTIASA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9713) Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9714)

Number_of_Residues

4